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Sigma-Aldrich
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021-61415566 800-8193336 |
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| Products Intro: |
Product Name:RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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| Products Intro: |
Product Name:ML-60218
CAS:577784-91-9
Purity:98% HPLC Package:100mg，250mg，1g
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| | RNA Polymerase III Inhibitor Basic information |
| Product Name: | RNA Polymerase III Inhibitor | | Synonyms: | RNA Polymerase III Inhibitor;2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide;InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-;transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218;RNA Polymerase III Inhibitor inhibitor | | CAS: | 577784-91-9 | | MF: | C19H15Cl2N3O2S2 | | MW: | 452.38 | | EINECS: | | | Product Categories: | | | Mol File: | 577784-91-9.mol |  |
| | RNA Polymerase III Inhibitor Chemical Properties |
| storage temp. | = -70C | | solubility | Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming) | | form | Off-white solid | | color | Off-white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| | RNA Polymerase III Inhibitor Usage And Synthesis |
| Description | ML60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from?S. Cerevisiae?as well as from human cells, IC50=32?mM and 27?mM respectively.1?? Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2 | | General Description | A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404). | | Biochem/physiol Actions | Product does not compete with ATP. | | References | 1) Wu?et al.?(2003),?Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell,?2?256
2) Yee?et al.?(2012),?Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open,?1(4)?295 |
| | RNA Polymerase III Inhibitor Preparation Products And Raw materials |
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