RNA Polymerase III Inhibitor
| 中文名称 | RNA Polymerase III Inhibitor |
|---|---|
| 中文同义词 | 化合物ML-60218 |
| 英文名称 | RNA Polymerase III Inhibitor |
| 英文同义词 | RNA Polymerase III Inhibitor;2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide;InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-;transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218;RNA Polymerase III Inhibitor inhibitor |
| CAS号 | 577784-91-9 |
| 分子式 | C19H15Cl2N3O2S2 |
| 分子量 | 452.38 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 577784-91-9.mol |
| 结构式 |  |
RNA Polymerase III Inhibitor 性质
| 储存条件 | = -70C |
|---|---|
| 溶解度 | 溶于 DMSO（最高 35 mg/ml）或乙醇（升温最高 5 mg/ml） |
| 形态 | 类白色固体 |
| 颜色 | 米白色 |
| 稳定性 | 可在-20°C下的DMSO或乙醇溶液保存长达2个月。 |
Combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis. ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest.
In in vitro transcription assays with purified double-layered particles (DLPs), ML-60218 shows dose-dependent inhibitory activity, indicating the viral nature of its target. ML-60218 is found to interfere with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation.