A-1155463
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- $36 - $1300
- Product name: A-1155463
- CAS: 1235034-55-5
- MF: C35H32FN5O4S2
- MW: 669.79
- EINECS:
- MDL Number:MFCD29924714
- Synonyms:A-1155463;2-[8-(1,3-Benzothiazol-2-ylcarbamoyl)-3,4-dihydro-2(1H)-isoquinolinyl]-5-(3-{4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy}propyl)-1,3-thiazole-4-carboxylic acid;2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-ynyl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid;A-1155463; A 1155463; A1155463.;4-Thiazolecarboxylic acid, 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-;2-(8-(Benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-(4-(3-(dimethylamino)prop-1-yn-1-yl)-2-fluorophenoxy)propyl)thiazole-4-carboxylic acid;Bcl-2 Family,Inhibitor,A-1155463,inhibit;Exenatide acetate (free base)
15 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number4663DP
- Product descriptionCID59447577
- Packaging25mg
- Price$834
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004756
- Product description2-[8-[(2-BENZOTHIAZOLYLAMINO)CARBONYL]-3,4-DIHYDRO-2(1H)-ISOQUINOLINYL]-5-[3-[4-[3-(DIMETHYLAMINO)-1-PROPYN-1-YL]-2-FLUOROPHENOXY]PROPYL]-4-THIAZOLECARBOXYLIC ACID 95.00%
- Packaging5MG
- Price$498.81
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6163
- Product descriptionA-1155463
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6163
- Product descriptionA-1155463
- Packaging25mg
- Price$404
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number27369
- Product descriptionA-1155463
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27369
- Product descriptionA-1155463
- Packaging5mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27369
- Product descriptionA-1155463
- Packaging10mg
- Price$216
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27369
- Product descriptionA-1155463
- Packaging25mg
- Price$450
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31004147
- Product descriptionA-1155463 98+%
- Packaging5mg
- Price$123
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004147
- Product descriptionA-1155463 98+%
- Packaging10mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004147
- Product descriptionA-1155463 98+%
- Packaging50mg
- Price$571
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004147
- Product descriptionA-1155463 98+%
- Packaging100mg
- Price$945
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9768
- Product descriptionA1155463 >98%
- Packaging250mg
- Price$1300
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML3162
- Product descriptionA-1155463 ≥98% (HPLC)
- Packaging5MG
- Price$123
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML3162
- Product descriptionA-1155463 ≥98% (HPLC)
- Packaging25MG
- Price$495
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4663DP | CID59447577 | 25mg | $834 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004756 | 2-[8-[(2-BENZOTHIAZOLYLAMINO)CARBONYL]-3,4-DIHYDRO-2(1H)-ISOQUINOLINYL]-5-[3-[4-[3-(DIMETHYLAMINO)-1-PROPYN-1-YL]-2-FLUOROPHENOXY]PROPYL]-4-THIAZOLECARBOXYLIC ACID 95.00% | 5MG | $498.81 | 2021-12-16 | Buy |
| ApexBio Technology | B6163 | A-1155463 | 5mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | B6163 | A-1155463 | 25mg | $404 | 2021-12-16 | Buy |
| Cayman Chemical | 27369 | A-1155463 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 27369 | A-1155463 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 27369 | A-1155463 | 10mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 27369 | A-1155463 | 25mg | $450 | 2024-03-01 | Buy |
| Crysdot | CD31004147 | A-1155463 98+% | 5mg | $123 | 2021-12-16 | Buy |
| Crysdot | CD31004147 | A-1155463 98+% | 10mg | $200 | 2021-12-16 | Buy |
| Crysdot | CD31004147 | A-1155463 98+% | 50mg | $571 | 2021-12-16 | Buy |
| Crysdot | CD31004147 | A-1155463 98+% | 100mg | $945 | 2021-12-16 | Buy |
| DC Chemicals | DC9768 | A1155463 >98% | 250mg | $1300 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML3162 | A-1155463 ≥98% (HPLC) | 5MG | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3162 | A-1155463 ≥98% (HPLC) | 25MG | $495 | 2024-03-01 | Buy |
Properties
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥67 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :1.11±0.36(Predicted)
color :Off-white to yellow
storage temp. :Store at -20°C
solubility :≥67 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :1.11±0.36(Predicted)
color :Off-white to yellow
Safety Information
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Description
A-1155463 Hydrochloride, is a potent and selective BCL-XL inhibitor with in vivo activity. A-1155463 is a proteolytically stable, cell-permeable and high affinity BH3 mimetic Ligand of BCL protein BCL-XL, binding to the target potently and selectively with a Ki value of <0.01nM (<10 pM), highly selective against closely related proteins of BCL-2 (Ki = 74nM, >7000-fold selectivity), BCL-W (Ki = 8 nM, >800-fold selectivity), and MCL-1 (Ki >444nM, >40000-fold selectivity). A-1155463, together with A-1331852 , represent the first-in-class small molecule BCL-XL selective inhibitors achieving clear-on-target in vivo activity with high potency and selectivity. In living cells, A-1155463, as anticipated, experts an effort to disrupt the tight-binding BCL-XL-BIM, but not BCL-2–BIM, complexes, killiSuppliers and manufacturers
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