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ChemicalBook >> CAS DataBase List >> AUY954

AUY954

AUY954 price.
  • $68 - $509
  • Product name: AUY954
  • CAS: 820240-77-5
  • MF: C25H20F3NO2S
  • MW: 455.5
  • EINECS:
  • MDL Number:
  • Synonyms:AUY954;β-Alanine, N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-;AUY-954 free base;AUY 954 free base,AUY954 free base;N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-β-alanine
4 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • 5mg
  • ManufacturerAK Scientific
  • Product number6228CS
  • Product description3-[[2-[4-Phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoicacid
  • Packaging5mg
  • Price$509
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number9000548
  • Product descriptionAUY954 ≥98%
  • Packaging500μg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number9000548
  • Product descriptionAUY954 ≥98%
  • Packaging1mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number9000548
  • Product descriptionAUY954 ≥98%
  • Packaging5mg
  • Price$370
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6228CS 3-[[2-[4-Phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoicacid 5mg $509 2021-12-16 Buy
Cayman Chemical 9000548 AUY954 ≥98% 500μg $68 2024-03-01 Buy
Cayman Chemical 9000548 AUY954 ≥98% 1mg $121 2024-03-01 Buy
Cayman Chemical 9000548 AUY954 ≥98% 5mg $370 2024-03-01 Buy

Properties

Boiling point :646.3±55.0 °C(Predicted)
Density :1.314±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form :A crystalline solid
pka :3.62±0.12(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells). It is highly selective for the S1P1 receptor with EC50 values of >10,000, 1,210, >1,000, and 340 nM for S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis. In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.