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AUY954
- CAS No.
- 820240-77-5
- Chemical Name:
- AUY954
- Synonyms
- AUY954;AUY-954 free base;AUY 954 free base,AUY954 free base;N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-β-alanine;β-Alanine, N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-
- CBNumber:
- CB54666241
- Molecular Formula:
- C25H20F3NO2S
- Molecular Weight:
- 455.5
- MDL Number:
- MOL File:
- 820240-77-5.mol
Last updated:2023-05-21 10:59:17
AUY954 price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 9000548 | AUY954 ≥98% | 820240-77-5 | 500μg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 9000548 | AUY954 ≥98% | 820240-77-5 | 1mg | $121 | 2024-03-01 | Buy |
Cayman Chemical | 9000548 | AUY954 ≥98% | 820240-77-5 | 5mg | $370 | 2024-03-01 | Buy |
AK Scientific | 6228CS | 3-[[2-[4-Phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoicacid | 820240-77-5 | 5mg | $509 | 2021-12-16 | Buy |
AUY954 Chemical Properties,Uses,Production
Description
AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P1; EC50 = 1.2 nM for stimulating GTPγS binding to S1P1 in CHO cells). It is highly selective for the S1P1 receptor with EC50 values of >10,000, 1,210, >1,000, and 340 nM for S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis. In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.
AUY954 Preparation Products And Raw materials
Raw materials
Preparation Products
AUY954 Suppliers
Global( 8)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7979 | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5596 | 58 |
AUY954
β-Alanine, N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-
AUY-954 free base
AUY 954 free base,AUY954 free base
N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-β-alanine
820240-77-5
C25H20F3NO2S