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AUY954

AUY954 구조식 이미지

카스 번호:: 820240-77-5

상품명:: AUY954

동의어(영문):: AUY954;AUY-954 free base;AUY 954 free base,AUY954 free base;N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-β-alanine;β-Alanine, N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-

CBNumber:: CB54666241

분자식:: C25H20F3NO2S

포뮬러 무게:: 455.5

MOL 파일:: 820240-77-5.mol

속성

안전

용도

공급 업체 8

AUY954 속성

끓는 점: 646.3±55.0 °C(Predicted)

밀도: 1.314±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml

물리적 상태: 결정성 고체

산도 계수 (pKa): 3.62±0.12(Predicted)

안전

AUY954 C화학적 특성, 용도, 생산

개요

AUY954 is an orally bioavailable and selective agonist of the sphingosine-1-phosphate receptor 1 (S1P₁; EC₅₀ = 1.2 nM for stimulating GTPγS binding to S1P₁ in CHO cells). It is highly selective for the S1P₁ receptor with EC₅₀ values of >10,000, 1,210, >1,000, and 340 nM for S1P₂, S1P₃, S1P₄, and S1P₅ receptors, respectively. AUY954 reduces circulating lymphocytes and prevents rejection of rat heart allografts. In a rat model of experimental autoimmune neuritis, chronic treatment with AUY954 (10 mg/kg), starting on the day of immunization, almost completely prevents peripheral paralysis. In the same model, it also decreases T cell, B cell, and macrophage infiltration and perivascular demyelination in sciatic nerves.

AUY954 준비 용품 및 원자재

원자재

준비 용품

AUY954 공급 업체

글로벌( 8)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7984	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5594	58