AX-024 hydrochloride
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- $40 - $1980
- Product name: AX-024 hydrochloride
- CAS: 1704801-24-0
- MF: C21H23ClFNO2
- MW: 375.87
- EINECS:
- MDL Number:MFCD31628548
- Synonyms:AX-024;AX024;AX 024;AX-024 hydrochloride;AX-024;1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride;AX 024,Interleukin Related,Inhibitor,inhibit,Tumor Necrosis Factor Receptor,AX024 hydrochloride,TNFR,Interferon-α/β receptor,AX024,AX-024,IFNAR,TNF Receptor,AX 024 hydrochloride,Interferon-alpha/beta receptor
16 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number8167EJ
- Product descriptionAX-024HCl
- Packaging25mg
- Price$856
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number27333
- Product descriptionAX-024 (hydrochloride)
- Packaging1mg
- Price$40
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27333
- Product descriptionAX-024 (hydrochloride)
- Packaging5mg
- Price$167
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27333
- Product descriptionAX-024 (hydrochloride)
- Packaging10mg
- Price$312
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27333
- Product descriptionAX-024 (hydrochloride)
- Packaging25mg
- Price$680
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-8002
- Product descriptionAX-024hydrochloride
- Packaging2mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-8002
- Product descriptionAX-024hydrochloride
- Packaging5mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-8002
- Product descriptionAX-024hydrochloride
- Packaging10mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-8002
- Product descriptionAX-024hydrochloride
- Packaging25mg
- Price$636
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-8002
- Product descriptionAX-024hydrochloride
- Packaging50mg
- Price$1140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-8002
- Product descriptionAX-024hydrochloride
- Packaging100mg
- Price$1980
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004992
- Product descriptionAX-024HCl 98%
- Packaging5mg
- Price$129
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004992
- Product descriptionAX-024HCl 98%
- Packaging10mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004992
- Product descriptionAX-024HCl 98%
- Packaging25mg
- Price$498
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004992
- Product descriptionAX-024HCl 98%
- Packaging50mg
- Price$777
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10545
- Product descriptionAX-024HCl >98%
- Packaging1g
- Price$1850
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8167EJ | AX-024HCl | 25mg | $856 | 2021-12-16 | Buy |
| Cayman Chemical | 27333 | AX-024 (hydrochloride) | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 27333 | AX-024 (hydrochloride) | 5mg | $167 | 2024-03-01 | Buy |
| Cayman Chemical | 27333 | AX-024 (hydrochloride) | 10mg | $312 | 2024-03-01 | Buy |
| Cayman Chemical | 27333 | AX-024 (hydrochloride) | 25mg | $680 | 2024-03-01 | Buy |
| ChemScene | CS-8002 | AX-024hydrochloride | 2mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-8002 | AX-024hydrochloride | 5mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-8002 | AX-024hydrochloride | 10mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-8002 | AX-024hydrochloride | 25mg | $636 | 2021-12-16 | Buy |
| ChemScene | CS-8002 | AX-024hydrochloride | 50mg | $1140 | 2021-12-16 | Buy |
| ChemScene | CS-8002 | AX-024hydrochloride | 100mg | $1980 | 2021-12-16 | Buy |
| Crysdot | CD31004992 | AX-024HCl 98% | 5mg | $129 | 2021-12-16 | Buy |
| Crysdot | CD31004992 | AX-024HCl 98% | 10mg | $235 | 2021-12-16 | Buy |
| Crysdot | CD31004992 | AX-024HCl 98% | 25mg | $498 | 2021-12-16 | Buy |
| Crysdot | CD31004992 | AX-024HCl 98% | 50mg | $777 | 2021-12-16 | Buy |
| DC Chemicals | DC10545 | AX-024HCl >98% | 1g | $1850 | 2021-12-16 | Buy |
Properties
storage temp. :-20°
solubility :Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming).
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
solubility :Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming).
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Safety Information
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Description
AX-024 is an inhibitor of the CD3ε-Nck interaction. It binds to the SH3.1 N-terminal domain of Nck1, preventing its binding to the proline-rich sequence of the CD3ε subunit of T cells. AX-024 inhibits T cell receptor-triggered T cell activation (IC50 = 1 nM for human T cells) and selectively decreases proliferation of T cells over B cells. It prevents CD4+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG35-55 mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 10 mg/kg per day for ten days starting on the day of immunization. AX-024 (50 mg/kg) prevents the infiltration of eosinophils, macrophages, and neutrophils into the airway, as well as prevents an increase in IL-4 levels in bronchoalveolar lavage fluid (BALF), in an ovalbumin-sensitized mouse model of allergic airway disease. It does not prevent the memory T cell response to an immunodominant B8R poxvirus antigen peptide or to infection by ectromelia virus (mousepox).Related product price
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