AZD 1080
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- $29 - $2839
- Product name: AZD 1080
- CAS: 612487-72-6
- MF: C19H18N4O2
- MW: 334.37
- EINECS:
- MDL Number:MFCD12031593
- Synonyms:AZD 1080;AZD1080;AZD-1080;2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile;2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile;2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile AZD1080;CS-809;AZD 1080;AZD-1080
30 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5MG
- 10mg
- 10mM(in 1mL DMSO)
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX6996
- Product descriptionAZD1080
- Packaging1mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX6996
- Product descriptionAZD1080
- Packaging25mg
- Price$527
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000375
- Product description2-HYDROXY-3-(5-(MORPHOLINOMETHYL)PYRIDIN-2-YL)-1H-INDOLE-5-CARBONITRILE 95.00%
- Packaging5MG
- Price$500.17
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging5mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging10mM(in 1mL DMSO)
- Price$242
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging10mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging25mg
- Price$620
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging50mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging100mg
- Price$1330
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2171
- Product descriptionAZD1080 98%
- Packaging25mg
- Price$396
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146240
- Product descriptionAZD1080 >98%
- Packaging100mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146240
- Product descriptionAZD1080 >98%
- Packaging250mg
- Price$1504.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146240
- Product descriptionAZD1080 >98%
- Packaging1g
- Price$2839
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16676
- Product descriptionAZD 1080 ≥95%
- Packaging1mg
- Price$29
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16676
- Product descriptionAZD 1080 ≥95%
- Packaging5mg
- Price$102
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16676
- Product descriptionAZD 1080 ≥95%
- Packaging10mg
- Price$145
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X6996 | AZD1080 | 1mg | $124 | 2021-12-16 | Buy |
| AK Scientific | X6996 | AZD1080 | 25mg | $527 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000375 | 2-HYDROXY-3-(5-(MORPHOLINOMETHYL)PYRIDIN-2-YL)-1H-INDOLE-5-CARBONITRILE 95.00% | 5MG | $500.17 | 2021-12-16 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 5mg | $190 | 2021-12-16 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 10mM(in 1mL DMSO) | $242 | 2021-12-16 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 10mg | $300 | 2021-12-16 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 25mg | $620 | 2021-12-16 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 50mg | $850 | 2021-12-16 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 100mg | $1330 | 2021-12-16 | Buy |
| Axon Medchem | Axon2171 | AZD1080 98% | 25mg | $396 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146240 | AZD1080 >98% | 100mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146240 | AZD1080 >98% | 250mg | $1504.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146240 | AZD1080 >98% | 1g | $2839 | 2021-12-16 | Buy |
| Cayman Chemical | 16676 | AZD 1080 ≥95% | 1mg | $29 | 2024-03-01 | Buy |
| Cayman Chemical | 16676 | AZD 1080 ≥95% | 5mg | $102 | 2024-03-01 | Buy |
| Cayman Chemical | 16676 | AZD 1080 ≥95% | 10mg | $145 | 2024-03-01 | Buy |
Properties
Boiling point :594.0±50.0 °C(Predicted)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥16.7 mg/mL in DMSO
form :solid
pka :8.32±0.50(Predicted)
color :Light yellow to orange
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥16.7 mg/mL in DMSO
form :solid
pka :8.32±0.50(Predicted)
color :Light yellow to orange
Safety Information
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Description
The two isoforms of glycogen synthase kinase 3, GSK3α and GSK3β, constitutively phosphorylate and inactivate glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer’s disease and osteogenesis. AZD 1080 is a potent, brain permeable inhibitor of GSK3α and GSK3β (Kis = 6.9 and 31 nM, respectively). It shows >14-fold selectivity against several kinases, receptors, enzymes, and ion channels. AZD 1080 inhibits tau phosphorylation in cells. It shows good bioavailability after oral administration in vivo, inhibiting hippocampal tau phosphorylation and reversing cognitive deficits induced by the NMDA receptor antagonist MK-801. In humans, oral AZD 1080 inhibits GSK3 activity in peripheral blood lymphocytes following an initial delay in response.Related product price
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$13.44-1504.5 - AZD-2858
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$49-3563.2
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