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ChemicalBook >> CAS DataBase List >> CHS-828

CHS-828

CHS-828 price.
  • $21 - $1900
  • Product name: CHS-828
  • CAS: 200484-11-3
  • MF: C19H22ClN5O
  • MW: 371.86
  • EINECS:
  • MDL Number:MFCD03700766
  • Synonyms:GMX 1778;N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine;1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine;GMX1778(CHS-828);2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine;CHS828;CHS 828;GMX1778, >98%;HS-828
28 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 10mg
  • 5mg
  • 10mM(in 1mL DMSO)
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-0064-M005
  • Product descriptionCHS-828 ≥98%(HPLC&NMR)
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3544AH
  • Product descriptionCHS-828
  • Packaging1g
  • Price$845
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA215361
  • Product descriptionGMX1778 98+%
  • Packaging1mg
  • Price$21
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA215361
  • Product descriptionGMX1778 98+%
  • Packaging5mg
  • Price$52
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA215361
  • Product descriptionGMX1778 98+%
  • Packaging10mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA215361
  • Product descriptionGMX1778 98+%
  • Packaging50mg
  • Price$114
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA215361
  • Product descriptionGMX1778 98+%
  • Packaging100mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA215361
  • Product descriptionGMX1778 98+%
  • Packaging250mg
  • Price$259
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA215361
  • Product descriptionGMX1778 98+%
  • Packaging1g
  • Price$676
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013854
  • Product descriptionCHS-828 95.00%
  • Packaging5MG
  • Price$185.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6031
  • Product descriptionGMX1778(CHS828)
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6031
  • Product descriptionGMX1778(CHS828)
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6031
  • Product descriptionGMX1778(CHS828)
  • Packaging50mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11021
  • Product descriptionCHS-828 ≥98%
  • Packaging5mg
  • Price$73
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11021
  • Product descriptionCHS-828 ≥98%
  • Packaging10mg
  • Price$138
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11021
  • Product descriptionCHS-828 ≥98%
  • Packaging25mg
  • Price$324
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-0064-M005 CHS-828 ≥98%(HPLC&NMR) 5mg $60 2021-12-16 Buy
AK Scientific 3544AH CHS-828 1g $845 2021-12-16 Buy
Ambeed A215361 GMX1778 98+% 1mg $21 2021-12-16 Buy
Ambeed A215361 GMX1778 98+% 5mg $52 2021-12-16 Buy
Ambeed A215361 GMX1778 98+% 10mg $67 2021-12-16 Buy
Ambeed A215361 GMX1778 98+% 50mg $114 2021-12-16 Buy
Ambeed A215361 GMX1778 98+% 100mg $160 2021-12-16 Buy
Ambeed A215361 GMX1778 98+% 250mg $259 2021-12-16 Buy
Ambeed A215361 GMX1778 98+% 1g $676 2021-12-16 Buy
American Custom Chemicals Corporation API0013854 CHS-828 95.00% 5MG $185.9 2021-12-16 Buy
ApexBio Technology B6031 GMX1778(CHS828) 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B6031 GMX1778(CHS828) 10mg $70 2021-12-16 Buy
ApexBio Technology B6031 GMX1778(CHS828) 50mg $280 2021-12-16 Buy
Cayman Chemical 11021 CHS-828 ≥98% 5mg $73 2024-03-01 Buy
Cayman Chemical 11021 CHS-828 ≥98% 10mg $138 2024-03-01 Buy
Cayman Chemical 11021 CHS-828 ≥98% 25mg $324 2024-03-01 Buy

Properties

Melting point :166-168°C
Boiling point :532.1±58.0 °C(Predicted)
Density :1.18±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: soluble20mg/mL, clear
pka :7.36±0.10(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :BOIPLTNGIAPDBY-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity. CHS-828 has potent cytotoxic effects in human breast (IC50 = 7.3 nM) and lung cancer (IC50 = 0.5 nM) cells both in vitro and in vivo. In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.

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