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ChemicalBook >> CAS DataBase List >> Cabazitaxel

Cabazitaxel

Cabazitaxel price.
  • $29 - $3980
  • Product name: Cabazitaxel
  • CAS: 183133-96-2
  • MF: C45H57NO14
  • MW: 835.93
  • EINECS:680-632-7
  • MDL Number:MFCD18827611
  • Synonyms:(2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;XRP 6258;Cabazitaxel;β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl;7β, 10β-DiMethoxydocetaxel;Cabazitaxel(XRP-6258)
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  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • BroadPharm
  • Cayman Chemical
  • Chemenu
  • Chem-Impex
  • ChemScene
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  • CSNpharm
  • DC Chemicals
  • Frontier Specialty Chemicals
  • JR MediChem
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
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  • ManufacturerAK Scientific
  • Product numberX7252
  • Product descriptionCabazitaxel
  • Packaging1mg
  • Price$29
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7252
  • Product descriptionCabazitaxel
  • Packaging500mg
  • Price$879
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005344
  • Product descriptionCABAZITAXEL 95.00%
  • Packaging5MG
  • Price$847
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005344
  • Product descriptionCABAZITAXEL 95.00%
  • Packaging50MG
  • Price$2425.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2157
  • Product descriptionCabazitaxel
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60306
  • Product descriptionCabazitaxel
  • Packaging20mg
  • Price$118
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS021351
  • Product description(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98%
  • Packaging100mg
  • Price$156
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS021351
  • Product description(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98%
  • Packaging250mg
  • Price$236
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS021351
  • Product description(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98%
  • Packaging1g
  • Price$586
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2677
  • Product descriptionCabazitaxel
  • Packaging5mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2677
  • Product descriptionCabazitaxel
  • Packaging10mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2677
  • Product descriptionCabazitaxel
  • Packaging100mg
  • Price$119
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2677
  • Product descriptionCabazitaxel
  • Packaging1g
  • Price$329
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2677
  • Product descriptionCabazitaxel
  • Packaging10g
  • Price$2290
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb153606
  • Product descriptionCabazitaxel >99% pure
  • Packaging5mg
  • Price$319.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb594549
  • Product descriptionCabazitaxel
  • Packaging20mg
  • Price$372.3
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7252 Cabazitaxel 1mg $29 2021-12-16 Buy
AK Scientific X7252 Cabazitaxel 500mg $879 2021-12-16 Buy
American Custom Chemicals Corporation API0005344 CABAZITAXEL 95.00% 5MG $847 2021-12-16 Buy
American Custom Chemicals Corporation API0005344 CABAZITAXEL 95.00% 50MG $2425.5 2021-12-16 Buy
ApexBio Technology B2157 Cabazitaxel 25mg $200 2021-12-16 Buy
Arctom CFN60306 Cabazitaxel 20mg $118 2021-12-16 Buy
Arctom AS021351 (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98% 100mg $156 2021-12-16 Buy
Arctom AS021351 (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98% 250mg $236 2021-12-16 Buy
Arctom AS021351 (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-((3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b ≥98% 1g $586 2021-12-16 Buy
AvaChem 2677 Cabazitaxel 5mg $39 2021-12-16 Buy
AvaChem 2677 Cabazitaxel 10mg $59 2021-12-16 Buy
AvaChem 2677 Cabazitaxel 100mg $119 2021-12-16 Buy
AvaChem 2677 Cabazitaxel 1g $329 2021-12-16 Buy
AvaChem 2677 Cabazitaxel 10g $2290 2021-12-16 Buy
Biorbyt Ltd orb153606 Cabazitaxel >99% pure 5mg $319.6 2021-12-16 Buy
Biorbyt Ltd orb594549 Cabazitaxel 20mg $372.3 2021-12-16 Buy

Properties

Melting point :180 °C
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

In June 2010, the U.S. FDA approved cabazitaxel (also referred to as XRP6258 and RPR 116258A) in combination with the steroid prednisone for the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC) for patients who were previously treated with a docetaxelcontaining regimen for late-stage disease.
Cabazitaxel is a semisynthetic analog of the natural product taxol, which is isolated from the bark of the yew tree. Cabazitaxel is a microtubule inhibitor that binds to the taxol-binding site of tubulin. Similar to other tubulin inhibitors of the taxol class, cabazitaxel inhibits microtubule disassembly resulting in mitotic blockade and cell death. Docetaxel, also a semisynthetic taxol analog, was approved by the FDA for the treatment of mCRPC in 2004. However, docetaxel is a substrate for P-gp, which is thought to contribute to the constitutive and acquired resistance of cancer cells to taxanes. Cabazitaxel has poor affinity for P-gp and showed antitumor activity in preclinical in vitro studies and in vivo tumor models that overexpress this protein. Cabazitaxel is synthesized on a commercial scale from 10-deacetylbaccatin .

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