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ChemicalBook >> CAS DataBase List >> Cuspin-1

Cuspin-1

Cuspin-1 price.
  • $57 - $525
  • Product name: Cuspin-1
  • CAS: 337932-29-3
  • MF: C13H10BrNO
  • MW: 276.1286
  • EINECS:
  • MDL Number:MFCD00452965
  • Synonyms:Cuspin-1;Methanone, (5-bromo-3-pyridinyl)(4-methylphenyl)-;Cuspin-1 >=98% (HPLC);Cuspin 1,Cuspin1;(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
7 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerAK Scientific
  • Product number5303CG
  • Product description3-Bromo-5-(4-methylbenzoyl)pyridine
  • Packaging25mg
  • Price$328
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number5303CG
  • Product description3-Bromo-5-(4-methylbenzoyl)pyridine
  • Packaging50mg
  • Price$525
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18526
  • Product descriptionCuspin-1 ≥98%
  • Packaging5mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18526
  • Product descriptionCuspin-1 ≥98%
  • Packaging10mg
  • Price$95
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18526
  • Product descriptionCuspin-1 ≥98%
  • Packaging25mg
  • Price$208
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18526
  • Product descriptionCuspin-1 ≥98%
  • Packaging50mg
  • Price$384
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberC845005
  • Product descriptionCuspin1
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5303CG 3-Bromo-5-(4-methylbenzoyl)pyridine 25mg $328 2021-12-16 Buy
AK Scientific 5303CG 3-Bromo-5-(4-methylbenzoyl)pyridine 50mg $525 2021-12-16 Buy
Cayman Chemical 18526 Cuspin-1 ≥98% 5mg $57 2024-03-01 Buy
Cayman Chemical 18526 Cuspin-1 ≥98% 10mg $95 2024-03-01 Buy
Cayman Chemical 18526 Cuspin-1 ≥98% 25mg $208 2024-03-01 Buy
Cayman Chemical 18526 Cuspin-1 ≥98% 50mg $384 2024-03-01 Buy
TRC C845005 Cuspin1 10mg $85 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 16 mg/mL; Ethanol: 1 mg/mL
form :A crystalline solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.