GDC-0032
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- $37 - $17576
- Product name: GDC-0032
- CAS: 1282512-48-4
- MF: C24H28N8O2
- MW: 460.53
- EINECS:
- MDL Number:MFCD26142641
- Synonyms:GDC-0032;RG7604/GDC-0032;4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl-1H-pyrazole-1-acetamide;GDC-0032/(RG-7604);2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide;Taselisib;4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide;GDC-0032 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide
28 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 5mg
- 10mg
- 2x5mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- 1000mg
- 10mM(in 1mL DMSO)
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1202-M001
- Product descriptionGDC-0032 ≥95%
- Packaging1mg
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1202-M005
- Product descriptionGDC-0032 ≥95%
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9344AF
- Product descriptionGDC-0032
- Packaging25mg
- Price$226
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging10mM(in 1mL DMSO)
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging25mg
- Price$265
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging100mg
- Price$615
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2927
- Product descriptionTaselisib-GDC0032|RG7604 99%
- Packaging5mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2927
- Product descriptionTaselisib-GDC0032|RG7604 99%
- Packaging2x5mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181246
- Product descriptionTaselisib (GDC-0032) >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181246
- Product descriptionTaselisib (GDC-0032) >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181246
- Product descriptionTaselisib (GDC-0032) >98%
- Packaging1000mg
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17387
- Product descriptionGDC-0032 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17387
- Product descriptionGDC-0032 ≥98%
- Packaging5mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17387
- Product descriptionGDC-0032 ≥98%
- Packaging10mg
- Price$161
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1202-M001 | GDC-0032 ≥95% | 1mg | $86 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1202-M005 | GDC-0032 ≥95% | 5mg | $130 | 2021-12-16 | Buy |
| AK Scientific | 9344AF | GDC-0032 | 25mg | $226 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 5mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 10mM(in 1mL DMSO) | $109 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 10mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 25mg | $265 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 100mg | $615 | 2021-12-16 | Buy |
| Axon Medchem | Axon2927 | Taselisib-GDC0032|RG7604 99% | 5mg | $99 | 2021-12-16 | Buy |
| Axon Medchem | Axon2927 | Taselisib-GDC0032|RG7604 99% | 2x5mg | $154 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181246 | Taselisib (GDC-0032) >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181246 | Taselisib (GDC-0032) >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181246 | Taselisib (GDC-0032) >98% | 1000mg | $2395.3 | 2021-12-16 | Buy |
| Cayman Chemical | 17387 | GDC-0032 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17387 | GDC-0032 ≥98% | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 17387 | GDC-0032 ≥98% | 10mg | $161 | 2024-03-01 | Buy |
Properties
Boiling point :783.3±70.0 °C(Predicted)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in H2O; ≥2.79 mg/mL in EtOH with gentle warming
form :solid
pka :15.54±0.50(Predicted)
color :White to off-white
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in H2O; ≥2.79 mg/mL in EtOH with gentle warming
form :solid
pka :15.54±0.50(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||
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Description
GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms α, δ, and γ (IC50s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kβ. It is over 1,000-fold selective for p100α over other PI3K-like kinases, including DNA-dependent protein kinase catalytic subunits, ATM, and ATR. GDC-0032 has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo, suppressing the growth of tumors in a mouse xenograft model at low drug dose levels.Related product price
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