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ChemicalBook >> CAS DataBase List >> GKA-50

GKA-50

GKA-50 price.
  • $197 - $6325
  • Product name: GKA-50
  • CAS: 851884-87-2
  • MF: C26H28N2O6
  • MW: 464.51
  • EINECS:
  • MDL Number:
  • Synonyms:GKA 50;GKA50;GKA-50;6-[[3-[(1S)-2-Methoxy-1-Methylethoxy]-5-[(1S)-1-Methyl-2-phenylethoxy]benzoyl]aMino]-3-pyridinecarboxylic Acid;OCBMECSFDVUYQN-ROUUACIJSA-N;GKA-50; GKA 50;3-Pyridinecarboxylic acid, 6-[[3-[(1S)-2-methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-
7 prices
Selected condition:
Brand
  • ChemScene
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerChemScene
  • Product numberCS-0008214
  • Product descriptionGKA50 >98.0%
  • Packaging5mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number65960
  • Product description6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylicAcid
  • Packaging50mg
  • Price$5750
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0849
  • Product descriptionGKA50 ≥98% (HPLC)
  • Packaging5mg
  • Price$197
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0849
  • Product descriptionGKA50 ≥98% (HPLC)
  • Packaging25mg
  • Price$652
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number5133
  • Product descriptionGKA50 ≥98%(HPLC)
  • Packaging10
  • Price$284
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberM264215
  • Product description6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylicAcid
  • Packaging100mg
  • Price$6325
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number255377
  • Product descriptionGKA 50
  • Packaging10mg
  • Price$593
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ChemScene CS-0008214 GKA50 >98.0% 5mg $550 2021-12-16 Buy
Medical Isotopes, Inc. 65960 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylicAcid 50mg $5750 2021-12-16 Buy
Sigma-Aldrich SML0849 GKA50 ≥98% (HPLC) 5mg $197 2024-03-01 Buy
Sigma-Aldrich SML0849 GKA50 ≥98% (HPLC) 25mg $652 2024-03-01 Buy
Tocris 5133 GKA50 ≥98%(HPLC) 10 $284 2021-12-16 Buy
TRC M264215 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylicAcid 100mg $6325 2021-12-16 Buy
Usbiological 255377 GKA 50 10mg $593 2021-12-16 Buy

Properties

Boiling point :607.0±55.0 °C(Predicted)
Density :1.247±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
pka :3.49±0.10(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P273 Avoid release to the environment.

Description

6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.

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