GNE-3511
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- $43 - $4850
- Product name: GNE-3511
- CAS: 1496581-76-0
- MF: C23H26F2N6O
- MW: 440.49
- EINECS:
- MDL Number:MFCD28502215
- Synonyms:GNE-3511;2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile;2-{[6-(3,3-DIFLUOROPYRROLIDIN-1-YL)-4-[1-(OXETAN-3-YL)PIPERIDIN-4-YL]PYRIDIN-2-YL]AMINO}PYRIDINE-4-CARBONITRILE;CS-2506;GNE3511;GNE 3511;2-((6-(3,3-DIFLUOROPYRROLIDIN-1-YL)-4-(1-(OXETAN-3-YL)PIPERIDIN-4-YL)PYRIDIN-2-YL)AMINO)ISONICOTINONITRILE;4-Pyridinecarbonitrile, 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-;GNE35Chemicalbook11
13 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- ManufacturerAK Scientific
- Product number3319DW
- Product descriptionCID72547959
- Packaging1mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19174
- Product descriptionGNE-3511 ≥98%
- Packaging1mg
- Price$43
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19174
- Product descriptionGNE-3511 ≥98%
- Packaging5mg
- Price$145
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19174
- Product descriptionGNE-3511 ≥98%
- Packaging10mg
- Price$209
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19174
- Product descriptionGNE-3511 ≥98%
- Packaging25mg
- Price$467
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-5852
- Product descriptionGNE-3511 99.98%
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5852
- Product descriptionGNE-3511 99.98%
- Packaging25mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5852
- Product descriptionGNE-3511 99.98%
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5852
- Product descriptionGNE-3511 99.98%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5852
- Product descriptionGNE-3511 99.98%
- Packaging500mg
- Price$4850
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10106
- Product descriptionGNE-3511 >98%
- Packaging250mg
- Price$1300
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10106
- Product descriptionGNE-3511 >98%
- Packaging1g
- Price$2600
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberG766103
- Product descriptionGNE-3511
- Packaging25mg
- Price$460
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3319DW | CID72547959 | 1mg | $145 | 2021-12-16 | Buy |
| Cayman Chemical | 19174 | GNE-3511 ≥98% | 1mg | $43 | 2024-03-01 | Buy |
| Cayman Chemical | 19174 | GNE-3511 ≥98% | 5mg | $145 | 2024-03-01 | Buy |
| Cayman Chemical | 19174 | GNE-3511 ≥98% | 10mg | $209 | 2024-03-01 | Buy |
| Cayman Chemical | 19174 | GNE-3511 ≥98% | 25mg | $467 | 2024-03-01 | Buy |
| ChemScene | CS-5852 | GNE-3511 99.98% | 10mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-5852 | GNE-3511 99.98% | 25mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-5852 | GNE-3511 99.98% | 50mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-5852 | GNE-3511 99.98% | 100mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-5852 | GNE-3511 99.98% | 500mg | $4850 | 2021-12-16 | Buy |
| DC Chemicals | DC10106 | GNE-3511 >98% | 250mg | $1300 | 2021-12-16 | Buy |
| DC Chemicals | DC10106 | GNE-3511 >98% | 1g | $2600 | 2021-12-16 | Buy |
| TRC | G766103 | GNE-3511 | 25mg | $460 | 2021-12-16 | Buy |
Properties
Boiling point :579.0±50.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:25.63(Max Conc. mg/mL);58.18(Max Conc. mM)
Methanol:1.0(Max Conc. mg/mL);2.27(Max Conc. mM) form :A crystalline solid
pka :7.23±0.40(Predicted)
color :Light yellow to yellow
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:25.63(Max Conc. mg/mL);58.18(Max Conc. mM)
Methanol:1.0(Max Conc. mg/mL);2.27(Max Conc. mM) form :A crystalline solid
pka :7.23±0.40(Predicted)
color :Light yellow to yellow
Safety Information
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Description
GNE-3511 is a selective and highly potent inhibitor of dual leucine zipper kinase (DLK). It also inhibits phosphorylated JNKand is highly selective for DLK over other MAP kinases. In an MPTP mouse model of Parkinson’s disease, a high dose of GNE-3511 completely suppresses phosphorylated c-Jun (p-c-Jun) expression, while a low dose moderately reduces its expression. Study has also shown that GNE03511 displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that GNE-3511 may have therapeutic potential in multiple indications.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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Hangzhou MolCore BioPharmatech Co.,Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd