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ChemicalBook >> CAS DataBase List >> GSK4027

GSK4027

GSK4027 price.
  • $44 - $3950
  • Product name: GSK4027
  • CAS: 2079896-25-4
  • MF: C17H21BrN4O
  • MW: 377.28
  • EINECS:
  • MDL Number:MFCD31692324
  • Synonyms:GSK4027;GSK4207;3(2H)-Pyridazinone, 4-bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenyl-3-piperidinyl]amino]-
Price10 Properties Safety Information Description
10 prices
Selected condition：
Brand
  • AK Scientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number3339EJ
  • Product description4-Bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one
  • Packaging5mg
  • Price$253
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBG166671
  • Product descriptionGSK 4027
  • Packaging10mg
  • Price$285
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23421
  • Product descriptionGSK4027
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23421
  • Product descriptionGSK4027
  • Packaging5mg
  • Price$140
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23421
  • Product descriptionGSK4027
  • Packaging10mg
  • Price$257
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging5mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging10mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging25mg
  • Price$1750
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging50mg
  • Price$2750
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020734
  • Product descriptionGSK4027 98.01%
  • Packaging100mg
  • Price$3950
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3339EJ 4-Bromo-2-methyl-5-[[(3R,5R)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one 5mg $253 2021-12-16 Buy
Biosynth Carbosynth BG166671 GSK 4027 10mg $285 2021-12-16 Buy
Cayman Chemical 23421 GSK4027 1mg $44 2024-03-01 Buy
Cayman Chemical 23421 GSK4027 5mg $140 2024-03-01 Buy
Cayman Chemical 23421 GSK4027 10mg $257 2024-03-01 Buy
ChemScene CS-0020734 GSK4027 98.01% 5mg $550 2021-12-16 Buy
ChemScene CS-0020734 GSK4027 98.01% 10mg $850 2021-12-16 Buy
ChemScene CS-0020734 GSK4027 98.01% 25mg $1750 2021-12-16 Buy
ChemScene CS-0020734 GSK4027 98.01% 50mg $2750 2021-12-16 Buy
ChemScene CS-0020734 GSK4027 98.01% 100mg $3950 2021-12-16 Buy

Properties

Boiling point :450.3±55.0 °C(Predicted)
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:50.0(Max Conc. mg/mL);132.53(Max Conc. mM)
form :A crystalline solid
pka :9.58±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

GSK4027 is a potent and selective chemical probe for the PCAF/GCN5 bromodomain. GSK4027 has PCAF TR-FRET pIC50 = 7.4 ; PCAF BROMOscan pKi = 8.9; GCN5 BROMOscan pKi = 8.9; PCAF NanoBRET pIC50 =7.2; BRD4 BD1 TR-FRET pIC50 < 4.3. GSK4027 shows high potency for the PCAF/GCN5 bromodomain, high solubility, cellular target engagement, and ≥18000-fold selectivity over the BET family, together with ≥70-fold selectivity over the wider bromodomain families. p300/CREB binding protein associated factor (PCAF/KAT2B) and general control nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in retroviral infection, inflammation pathways, and cancer development.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Aladdin Scientific BOC Sciences Hangzhou Synstar pharmaceutical Technology CO.,Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. Shanghai hongqu biomedical technology co. LTD Kaifeng Mingren Pharmaceutical Co.,LTD Shanghai Yifei Biotechnology Co. , Ltd. RD International Technology Co., Limited TargetMol Chemicals Inc.