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ChemicalBook >> CAS DataBase List >> GSK461364

GSK461364

GSK461364 price.
  • $34 - $3990
  • Product name: GSK461364
  • CAS: 929095-18-1
  • MF: C27H28F3N5O2S
  • MW: 543.6
  • EINECS:200-258-5
  • MDL Number:MFCD12755419
  • Synonyms:(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide;GSK-461364A;GSK461364(GSK-461364);5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl];5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phen;GSK461364;GSK-461364;GSK4613
29 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 1mg
  • 2.5mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 2x25mg
  • 100mg
  • 200mg
  • 250mg
  • 1G
  • ManufacturerAK Scientific
  • Product numberX7374
  • Product description5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide
  • Packaging250mg
  • Price$2474
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000326
  • Product description5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00%
  • Packaging5MG
  • Price$598
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000326
  • Product description5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00%
  • Packaging1G
  • Price$3240
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8441
  • Product descriptionGSK461364
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60399
  • Product descriptionGSK461364 ≥98%
  • Packaging5mg
  • Price$188
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1688
  • Product descriptionGSK461364 99%
  • Packaging5mg
  • Price$115.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1688
  • Product descriptionGSK461364 99%
  • Packaging2x25mg
  • Price$594
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM43315
  • Product descriptionGSK 461364
  • Packaging10mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFM43315
  • Product descriptionGSK 461364
  • Packaging50mg
  • Price$612.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18099
  • Product descriptionGSK461364 ≥95%
  • Packaging1mg
  • Price$34
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18099
  • Product descriptionGSK461364 ≥95%
  • Packaging5mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18099
  • Product descriptionGSK461364 ≥95%
  • Packaging10mg
  • Price$216
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18099
  • Product descriptionGSK461364 ≥95%
  • Packaging25mg
  • Price$493
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM161276
  • Product description5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide 98%
  • Packaging100mg
  • Price$393
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0069
  • Product descriptionGSK461364 99.82%
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0069
  • Product descriptionGSK461364 99.82%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7374 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide 250mg $2474 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000326 5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00% 5MG $598 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000326 5-[6-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-BENZIMIDAZOL-1-YL]-3-[(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY]-2-THIOPHENECARBOXAMIDE 95.00% 1G $3240 2021-12-16 Buy
ApexBio Technology A8441 GSK461364 10mg $150 2021-12-16 Buy
Arctom CFN60399 GSK461364 ≥98% 5mg $188 2021-12-16 Buy
Axon Medchem Axon1688 GSK461364 99% 5mg $115.5 2021-12-16 Buy
Axon Medchem Axon1688 GSK461364 99% 2x25mg $594 2021-12-16 Buy
Biosynth Carbosynth FM43315 GSK 461364 10mg $175 2021-12-16 Buy
Biosynth Carbosynth FM43315 GSK 461364 50mg $612.5 2021-12-16 Buy
Cayman Chemical 18099 GSK461364 ≥95% 1mg $34 2024-03-01 Buy
Cayman Chemical 18099 GSK461364 ≥95% 5mg $117 2024-03-01 Buy
Cayman Chemical 18099 GSK461364 ≥95% 10mg $216 2024-03-01 Buy
Cayman Chemical 18099 GSK461364 ≥95% 25mg $493 2024-03-01 Buy
Chemenu CM161276 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide 98% 100mg $393 2021-12-16 Buy
ChemScene CS-0069 GSK461364 99.82% 5mg $80 2021-12-16 Buy
ChemScene CS-0069 GSK461364 99.82% 10mg $150 2021-12-16 Buy

Properties

Melting point :>150°C (dec.)
Boiling point :658.0±65.0 °C(Predicted)
Density :1.39
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :15.16±0.50(Predicted)
form :Solid
color :Off-White to Light Beige

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
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Description

Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. GSK461364 is a potent, reversible inhibitor of Plk1 (Ki = 2.2 nM). It is less effective against Plk2 and Plk3 (Kis = 860 and 1,000 nM, respectively) and at least 1,000-fold selective for Plk1 over a panel of 48 other kinases. GSK461364 dose-dependently halts cell cycling in diverse proliferating cancer cell lines and, at higher doses, triggers apoptosis. It appears to be more effective against p53-deficient tumors and is able to cross the blood-brain barrier. GSK461364 is effective in vivo, inducing tumor growth inhibition or growth delay in xenograft models in mice.

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