HJC0197
- $37 - $1800
- Product name: HJC0197
- CAS: 1383539-73-8
- MF: C19H21N3OS
- MW: 339.45
- EINECS:
- MDL Number:MFCD27966183
- Synonyms:HJC0197;5-Pyrimidinecarbonitrile, 4-cyclopentyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-;HJC 0197 (HJC0197);HJC0197,cAMP-signaling,activation,GEF,cellular,Ras,inhibit,HJC-0197,HJC 0197,phosphorylation,processes,Inhibitor;6-Cyclopentyl-2-((2,5-dimethylbenzyl)thio)-4-oxo-1,4-dihydropyrimidine-5-carbonitrile
9 prices
Selected condition:
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- DC Chemicals
Package
- 1mg
- 5MG
- 10mg
- 100mg
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0002135
- Product description4-CYCLOPENTYL-2-(2,5-DIMETHYLBENZYLSULFANYL)-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE 95.00%
- Packaging5MG
- Price$495.22
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3387
- Product descriptionHJC0197
- Packaging5mg
- Price$192
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3387
- Product descriptionHJC0197
- Packaging10mg
- Price$321
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19092
- Product descriptionHJC0197 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19092
- Product descriptionHJC0197 ≥98%
- Packaging5mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19092
- Product descriptionHJC0197 ≥98%
- Packaging10mg
- Price$283
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC21116
- Product descriptionHJC0197 >98%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21116
- Product descriptionHJC0197 >98%
- Packaging250mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC21116
- Product descriptionHJC0197 >98%
- Packaging1g
- Price$1800
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
American Custom Chemicals Corporation | INB0002135 | 4-CYCLOPENTYL-2-(2,5-DIMETHYLBENZYLSULFANYL)-6-OXO-1,6-DIHYDROPYRIMIDINE-5-CARBONITRILE 95.00% | 5MG | $495.22 | 2021-12-16 | Buy |
ApexBio Technology | C3387 | HJC0197 | 5mg | $192 | 2021-12-16 | Buy |
ApexBio Technology | C3387 | HJC0197 | 10mg | $321 | 2021-12-16 | Buy |
Cayman Chemical | 19092 | HJC0197 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 19092 | HJC0197 ≥98% | 5mg | $169 | 2024-03-01 | Buy |
Cayman Chemical | 19092 | HJC0197 ≥98% | 10mg | $283 | 2024-03-01 | Buy |
DC Chemicals | DC21116 | HJC0197 >98% | 100mg | $450 | 2021-12-16 | Buy |
DC Chemicals | DC21116 | HJC0197 >98% | 250mg | $900 | 2021-12-16 | Buy |
DC Chemicals | DC21116 | HJC0197 >98% | 1g | $1800 | 2021-12-16 | Buy |
Properties
solubility :DMF: 10 mg/ml; DMF:PBS(pH7.2) (1:2): 0.2 mg/ml; DMSO: 5 mg/ml
form :A crystalline solid
color :White to off-white
form :A crystalline solid
color :White to off-white
Safety Information
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Description
Exchange protein activated by cAMP (Epac) proteins mediate cAMP signaling independent of protein kinase A (PKA). HJC0197 is a cell-permeable inhibitor of Epac1 and Epac2 (IC50 = 5.9 μM for Epac2). It inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM, but has no effect on cAMP-induced type I and II PKA activity at this concentration. Pretreatment of HEK293 cells expressing either Epac1 or Epac2 with 10 μM HJC0197 completely blocks Epac-mediated phosphorylation of Akt. HJC0197 has been used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures.Suppliers and manufacturers
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