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ChemicalBook >> CAS DataBase List >> Herboxidiene

Herboxidiene

Herboxidiene price.
  • $225 - $542
  • Product name: Herboxidiene
  • CAS: 142861-00-5
  • MF: C25H42O6
  • MW: 438.6
  • EINECS:
  • MDL Number:MFCD09752733
  • Synonyms:Herboxidiene;GEX1A;TAN-1609;2-((2R,5S,6S)-6-((S,2E,4E)-7-((2R,3R)-3-((2R,3R,4R)-4-hydroxy-3-methoxypentan-2-yl)-2-methyloxiran-2-yl)-6-methylhepta-2,4-dien-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)acetic acid;L-glycero-L-gluco-Heptitol, 5,6-anhydro-6-C-[(2S,3E,5E)-6-[(2S,3S,6R)-6-(carboxymethyl)tetrahydro-3-methyl-2H-pyran-2-yl]-2-methyl-3,5-heptadien-1-yl]-1,4,7-trideoxy-4-methyl-3-O-methyl-
4 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • 5MG
  • ManufacturerAK Scientific
  • Product number8504CP
  • Product descriptionHerboxidiene
  • Packaging1mg
  • Price$542
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0019328
  • Product descriptionHERBOXYDIENE 95.00%
  • Packaging5MG
  • Price$495.19
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25136
  • Product descriptionHerboxidiene
  • Packaging500μg
  • Price$225
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25136
  • Product descriptionHerboxidiene
  • Packaging1mg
  • Price$338
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8504CP Herboxidiene 1mg $542 2021-12-16 Buy
American Custom Chemicals Corporation API0019328 HERBOXYDIENE 95.00% 5MG $495.19 2021-12-16 Buy
Cayman Chemical 25136 Herboxidiene 500μg $225 2024-03-01 Buy
Cayman Chemical 25136 Herboxidiene 1mg $338 2024-03-01 Buy

Properties

Boiling point :567.9±35.0 °C(Predicted)
Density :1.056±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO or Ethanol
pka :4.38±0.10(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
LogP :3.459 (est)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit SF3b.2?Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.3?Displays anti-angiogenic activity via down-regulation of VEGFR-2 and HIF-1α.4?Spliceosome inhibitors have attracted enormous attention due to their potential use in cancer treatment.5