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BOC Sciences
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Product Name:Herboxidiene
CAS:142861-00-5
Purity:98% Remarks:Herboxidiene is a substance with herbicidal activity produced by Streptomyces chromofuscus. It has s
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Shanghai Hongye Biotechnology Co. Ltd
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sales@glpbio.cn |
| Products Intro: |
Product Name:Herboxidiene
CAS:142861-00-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Jinan ponder chemical co. LTD
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0531-0000 |
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| Products Intro: |
Product Name:142861-00-5
CAS:142861-00-5
Purity:99% HPLC Package:1KG;500G;100G;50G;1G
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Herboxidiene manufacturers
- Herboxidiene
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- $845.00 / 1mg
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2024-10-28
- CAS:142861-00-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Herboxidiene Basic information |
| Product Name: | Herboxidiene | | Synonyms: | Herboxidiene;GEX1A;TAN-1609;2-((2R,5S,6S)-6-((S,2E,4E)-7-((2R,3R)-3-((2R,3R,4R)-4-hydroxy-3-methoxypentan-2-yl)-2-methyloxiran-2-yl)-6-methylhepta-2,4-dien-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)acetic acid;L-glycero-L-gluco-Heptitol, 5,6-anhydro-6-C-[(2S,3E,5E)-6-[(2S,3S,6R)-6-(carboxymethyl)tetrahydro-3-methyl-2H-pyran-2-yl]-2-methyl-3,5-heptadien-1-yl]-1,4,7-trideoxy-4-methyl-3-O-methyl- | | CAS: | 142861-00-5 | | MF: | C25H42O6 | | MW: | 438.6 | | EINECS: | | | Product Categories: | | | Mol File: | 142861-00-5.mol |  |
| | Herboxidiene Chemical Properties |
| Boiling point | 567.9±35.0 °C(Predicted) | | density | 1.056±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO or Ethanol | | pka | 4.38±0.10(Predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | LogP | 3.459 (est) |
| | Herboxidiene Usage And Synthesis |
| Description | Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit SF3b.2?Specifically targets SAP155, a subunit of SF3b responsible for pre-mRNA splicing.3?Displays anti-angiogenic activity via down-regulation of VEGFR-2 and HIF-1α.4?Spliceosome inhibitors have attracted enormous attention due to their potential use in cancer treatment.5 | | Uses | Herboxidiene is an anticancer agent. Herboxidiene is used in the lowering of plasma cholesterol, pre-mRNA splicing-modulatory action and in anti-tumor activity in numerous cell lines. It also exhibits herbicidal properties. | | References | 1) Miller-Wideman?et al.?(1992),?Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physio-chemical and biological properties; J. Antibiot. (Tokyo),?45?914
2) Gao?et al.?(2013),?Comparison of splicing factor 3b inhibitors in human cells; Chembiochem,?14?49
3) Hasegawa?et al.?(2011),?Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product; ACS Chem. Biol.,?6?229
4) Jung?et al.?(2015),?Antiangiogenic activity of herboxidiene via downregulation of vascular endothelial growth factor receptor-2 and hypoxia-inducible factor-1α; Arch. Pharm. Res.,?38?1728
5) Martinez-Montiel?et al.?(2016),?Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment;?Biomed. Res. Int.,?2016?3681094 |
| | Herboxidiene Preparation Products And Raw materials |
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