IPI-549
|
- $36 - $1141
- Product name: IPI-549
- CAS: 1693758-51-8
- MF: C30H24N8O2
- MW: 528.56
- EINECS:-0
- MDL Number:MFCD30533720
- Synonyms:IPI-549;(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;IPI-549(IPI549);IPI-549, 98%, a potent and selective PI3Kγ Inhibitor;CS-2414;IPI-549; IPI 549; IPI549.;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]-;IPI549 (Eganelisib)
21 prices
Selected condition：
Brand
- Activate Scientific
- American Custom Chemicals Corporation
- Apolloscientific
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerActivate Scientific
- Product numberAS118143
- Product descriptionIPI-549 98+%
- Packaging1mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS118143
- Product descriptionIPI-549 98+%
- Packaging100mg
- Price$1141
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPRK0000449
- Product description(S)-2-AMINO-N-(1-(8-((1-METHYL-1H-PYRAZOL-4-YL)ETHYNYL)-1-OXO-2-PHENYL-1,2-DIHYDROISOQUINOLIN-3-YL)ETHYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE 95.00%
- Packaging5MG
- Price$458.64
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0153
- Product descriptionIPI-549
- Packaging1mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0153
- Product descriptionIPI-549
- Packaging5mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0153
- Product descriptionIPI-549
- Packaging10mg
- Price$196
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number26416
- Product descriptionIPI-549
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number26416
- Product descriptionIPI-549
- Packaging5mg
- Price$120
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number26416
- Product descriptionIPI-549
- Packaging10mg
- Price$223
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number26416
- Product descriptionIPI-549
- Packaging25mg
- Price$384
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM250214
- Product description(S)-2-Amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98%
- Packaging100mg
- Price$439
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6106
- Product descriptionIPI549 99.65%
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6106
- Product descriptionIPI549 99.65%
- Packaging10mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6106
- Product descriptionIPI549 99.65%
- Packaging25mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6106
- Product descriptionIPI549 99.65%
- Packaging50mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6106
- Product descriptionIPI549 99.65%
- Packaging100mg
- Price$660
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Activate Scientific | AS118143 | IPI-549 98+% | 1mg | $79 | 2021-12-16 | Buy |
| Activate Scientific | AS118143 | IPI-549 98+% | 100mg | $1141 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PRK0000449 | (S)-2-AMINO-N-(1-(8-((1-METHYL-1H-PYRAZOL-4-YL)ETHYNYL)-1-OXO-2-PHENYL-1,2-DIHYDROISOQUINOLIN-3-YL)ETHYL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE 95.00% | 5MG | $458.64 | 2021-12-16 | Buy |
| Apolloscientific | BISN0153 | IPI-549 | 1mg | $80 | 2021-12-16 | Buy |
| Apolloscientific | BISN0153 | IPI-549 | 5mg | $138 | 2021-12-16 | Buy |
| Apolloscientific | BISN0153 | IPI-549 | 10mg | $196 | 2021-12-16 | Buy |
| Cayman Chemical | 26416 | IPI-549 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 26416 | IPI-549 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 26416 | IPI-549 | 10mg | $223 | 2024-03-01 | Buy |
| Cayman Chemical | 26416 | IPI-549 | 25mg | $384 | 2024-03-01 | Buy |
| Chemenu | CM250214 | (S)-2-Amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 98% | 100mg | $439 | 2021-12-16 | Buy |
| ChemScene | CS-6106 | IPI549 99.65% | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-6106 | IPI549 99.65% | 10mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-6106 | IPI549 99.65% | 25mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-6106 | IPI549 99.65% | 50mg | $240 | 2021-12-16 | Buy |
| ChemScene | CS-6106 | IPI549 99.65% | 100mg | $660 | 2021-12-16 | Buy |
Properties
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :10.81±0.46(Predicted)
form :solid
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference :1693758-51-8
storage temp. :-20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :10.81±0.46(Predicted)
form :solid
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference :1693758-51-8
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
IPI-549 (1693758-51-8) is a potent and highly selective inhibitor of PI3K-γ in both biochemical (IC50?= 16 nM) and cellular (IC50?= 12.2 nM) assays.1?Macrophage PI3K-γ has been found to be a critical switch between immune stimulation and suppression.2?IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3K-γ inhibition via IPI-549.3?IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines.3?IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance.4Related product price
- CL 82198 HYDROCHLORIDE
$40-1732.75 - LFM-A13
$55-1462.58 - ZM 336372
$43-1815