IRAK-1/4 INHIBITOR I
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- $32 - $1092
- Product name: IRAK-1/4 INHIBITOR I
- CAS: 509093-47-4
- MF: C20H21N5O4
- MW: 395.41
- EINECS:
- MDL Number:MFCD09752602
- Synonyms:3-Nitro-N-(1-(2-morpholin-4-ylethyl)-1H-benzimidazol-2-yl)benzamide;BenzaMide, N-[1-[2-(4-Morpholinyl)ethyl]-1H-benziMidazol-2-yl]-3-nitro-;Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor;InSolution? Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor ;IIRAK-1-4 Inhibitor I;1-(2-(4-Morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole;N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole;IRAK-1/4 INHIBITOR I
29 prices
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Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5MG
- 50
- 1MG
- 10mg
- 20mg
- 25MG
- 50mg
- 100mg
- 250mg
- 10
- 1g
- ManufacturerAK Scientific
- Product number3747AH
- Product descriptionIRAK-1/4 Inhibitor I
- Packaging1g
- Price$631
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000806
- Product descriptionIRAK-1/4 INHIBITOR I 95.00%
- Packaging1MG
- Price$415.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000806
- Product descriptionIRAK-1/4 INHIBITOR I 95.00%
- Packaging5MG
- Price$476
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000806
- Product descriptionIRAK-1/4 INHIBITOR I 95.00%
- Packaging25MG
- Price$641
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3505
- Product descriptionIRAK-1/4 Inhibitor I
- Packaging20mg
- Price$236
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17540
- Product descriptionIRAK-1/4 Inhibitor ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17540
- Product descriptionIRAK-1/4 Inhibitor ≥98%
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17540
- Product descriptionIRAK-1/4 Inhibitor ≥98%
- Packaging10mg
- Price$199
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17540
- Product descriptionIRAK-1/4 Inhibitor ≥98%
- Packaging25mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM161637
- Product descriptionN-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide 98%
- Packaging100mg
- Price$554
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0704
- Product descriptionIRAK-1/4 Inhibitor I 99.88%
- Packaging5mg
- Price$107
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0704
- Product descriptionIRAK-1/4 Inhibitor I 99.88%
- Packaging10mg
- Price$146
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0704
- Product descriptionIRAK-1/4 Inhibitor I 99.88%
- Packaging50mg
- Price$653
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0704
- Product descriptionIRAK-1/4 Inhibitor I 99.88%
- Packaging100mg
- Price$1092
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31001709
- Product descriptionIRAK-1/4 Inhibitor I 98+%
- Packaging5mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31001709
- Product descriptionIRAK-1/4 Inhibitor I 98+%
- Packaging10mg
- Price$79
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3747AH | IRAK-1/4 Inhibitor I | 1g | $631 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000806 | IRAK-1/4 INHIBITOR I 95.00% | 1MG | $415.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000806 | IRAK-1/4 INHIBITOR I 95.00% | 5MG | $476 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000806 | IRAK-1/4 INHIBITOR I 95.00% | 25MG | $641 | 2021-12-16 | Buy |
| ApexBio Technology | A3505 | IRAK-1/4 Inhibitor I | 20mg | $236 | 2021-12-16 | Buy |
| Cayman Chemical | 17540 | IRAK-1/4 Inhibitor ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17540 | IRAK-1/4 Inhibitor ≥98% | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 17540 | IRAK-1/4 Inhibitor ≥98% | 10mg | $199 | 2024-03-01 | Buy |
| Cayman Chemical | 17540 | IRAK-1/4 Inhibitor ≥98% | 25mg | $456 | 2024-03-01 | Buy |
| Chemenu | CM161637 | N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide 98% | 100mg | $554 | 2021-12-16 | Buy |
| ChemScene | CS-0704 | IRAK-1/4 Inhibitor I 99.88% | 5mg | $107 | 2021-12-16 | Buy |
| ChemScene | CS-0704 | IRAK-1/4 Inhibitor I 99.88% | 10mg | $146 | 2021-12-16 | Buy |
| ChemScene | CS-0704 | IRAK-1/4 Inhibitor I 99.88% | 50mg | $653 | 2021-12-16 | Buy |
| ChemScene | CS-0704 | IRAK-1/4 Inhibitor I 99.88% | 100mg | $1092 | 2021-12-16 | Buy |
| Crysdot | CD31001709 | IRAK-1/4 Inhibitor I 98+% | 5mg | $58 | 2021-12-16 | Buy |
| Crysdot | CD31001709 | IRAK-1/4 Inhibitor I 98+% | 10mg | $79 | 2021-12-16 | Buy |
Properties
Density :1.40
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL
form :Yellow crystalline solid
pka :11.54±0.43(Predicted)
color :off-white to light yellow
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL
form :Yellow crystalline solid
pka :11.54±0.43(Predicted)
color :off-white to light yellow
Safety Information
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Description
Interleukin-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. Dysregulation of TIR signaling, typified by increased NF-κB activity, results in the development of some cancers and other diseases, making the development of IRAK inhibitors a potential therapeutic strategy. IRAK-1/4 inhibitor is a benzimidazole that disrupts the activity of IRAK-1 and -4 with IC50 values of 0.3 and 0.2 μM, respectively. It demonstrates IC50 values >10 μM in a panel of 27 other kinases tested. This compound has been used to inhibit a pro-inflammatory response in microglia isolated from clinically diagnosed Alzheimer’s disease patients.More related product prices
DEMETON SRelated product price
- DEMETON S
$60-1593.9 - 1-(2-DIETHYLAMINO-ETHYL)-1H-BENZOIMIDAZOL-2-YLAMINE
$58-1295.03 - IRAK-1/4 INHIBITOR I
$32-1092
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