JZL 195
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- $60 - $816
- Product name: JZL 195
- CAS: 1210004-12-8
- MF: C24H23N3O5
- MW: 433.46
- EINECS:
- MDL Number:MFCD18382122
- Synonyms:JZL 195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;CS-1586;JZL-195;JZL 195;JZL195;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
20 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- Usbiological
Package
- 50
- 10
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number3756AH
- Product description4-Nitrophenyl4-(3-phenoxybenzyl)piperazine-1-carboxylate
- Packaging10mg
- Price$222
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7701
- Product descriptionJZL195
- Packaging50mg
- Price$605
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13668
- Product descriptionJZL 195 ≥98%
- Packaging5mg
- Price$61
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13668
- Product descriptionJZL 195 ≥98%
- Packaging10mg
- Price$112
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13668
- Product descriptionJZL 195 ≥98%
- Packaging50mg
- Price$468
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13668
- Product descriptionJZL 195 ≥98%
- Packaging100mg
- Price$816
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM169976
- Product description4-nitrophenyl4-(3-phenoxybenzyl)piperazine-1-carboxylate 98%
- Packaging100mg
- Price$439
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3374
- Product descriptionJZL195 99.75%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3374
- Product descriptionJZL195 99.75%
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3374
- Product descriptionJZL195 99.75%
- Packaging50mg
- Price$461
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3374
- Product descriptionJZL195 99.75%
- Packaging100mg
- Price$806
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004274
- Product descriptionJZL195 98+%
- Packaging50mg
- Price$365
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004274
- Product descriptionJZL195 98+%
- Packaging100mg
- Price$639
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8352
- Product descriptionJZL-195 >98%
- Packaging100mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8352
- Product descriptionJZL-195 >98%
- Packaging250mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0257
- Product descriptionJZL195 ≥98% (HPLC)
- Packaging5mg
- Price$127
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3756AH | 4-Nitrophenyl4-(3-phenoxybenzyl)piperazine-1-carboxylate | 10mg | $222 | 2021-12-16 | Buy |
| ApexBio Technology | B7701 | JZL195 | 50mg | $605 | 2021-12-16 | Buy |
| Cayman Chemical | 13668 | JZL 195 ≥98% | 5mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 13668 | JZL 195 ≥98% | 10mg | $112 | 2024-03-01 | Buy |
| Cayman Chemical | 13668 | JZL 195 ≥98% | 50mg | $468 | 2024-03-01 | Buy |
| Cayman Chemical | 13668 | JZL 195 ≥98% | 100mg | $816 | 2024-03-01 | Buy |
| Chemenu | CM169976 | 4-nitrophenyl4-(3-phenoxybenzyl)piperazine-1-carboxylate 98% | 100mg | $439 | 2021-12-16 | Buy |
| ChemScene | CS-3374 | JZL195 99.75% | 5mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-3374 | JZL195 99.75% | 10mg | $108 | 2021-12-16 | Buy |
| ChemScene | CS-3374 | JZL195 99.75% | 50mg | $461 | 2021-12-16 | Buy |
| ChemScene | CS-3374 | JZL195 99.75% | 100mg | $806 | 2021-12-16 | Buy |
| Crysdot | CD31004274 | JZL195 98+% | 50mg | $365 | 2021-12-16 | Buy |
| Crysdot | CD31004274 | JZL195 98+% | 100mg | $639 | 2021-12-16 | Buy |
| DC Chemicals | DC8352 | JZL-195 >98% | 100mg | $300 | 2021-12-16 | Buy |
| DC Chemicals | DC8352 | JZL-195 >98% | 250mg | $600 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML0257 | JZL195 ≥98% (HPLC) | 5mg | $127 | 2024-03-01 | Buy |
Properties
Boiling point :581.8±50.0 °C(Predicted)
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: ≥5mg/mL at warmed
pka :6.13±0.10(Predicted)
form :powder
color :white to beige
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: ≥5mg/mL at warmed
pka :6.13±0.10(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.Suppliers and manufacturers
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Shanghai Boyle Chemical Co., Ltd.
