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ChemicalBook >> CAS DataBase List >> K 02288

K 02288

K 02288 price.
  • $37 - $1700
  • Product name: K 02288
  • CAS: 1431985-92-0
  • MF: C20H20N2O4
  • MW: 352.38
  • EINECS:
  • MDL Number:MFCD26936347
  • Synonyms:LM-3151 K02288;K 02288;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-;K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K 02288(K 02288a);K 02288a;K 02288 USP/EP/BP
24 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 10
  • 1mg
  • 50
  • 10mg
  • 10mM(in 1mL DMSO)
  • 25MG
  • 50mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberY1876
  • Product descriptionK02288
  • Packaging10mg
  • Price$243
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY1876
  • Product descriptionK02288
  • Packaging50mg
  • Price$771
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151373
  • Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151373
  • Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
  • Packaging10mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151373
  • Product description3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+%
  • Packaging50mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2286
  • Product descriptionK02288
  • Packaging10mM(in 1mL DMSO)
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2286
  • Product descriptionK02288
  • Packaging50mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16678
  • Product descriptionK02288 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16678
  • Product descriptionK02288 ≥98%
  • Packaging5mg
  • Price$134
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16678
  • Product descriptionK02288 ≥98%
  • Packaging10mg
  • Price$231
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16678
  • Product descriptionK02288 ≥98%
  • Packaging50mg
  • Price$793
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM249406
  • Product description3-(6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol 98%
  • Packaging50mg
  • Price$404
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3395
  • Product descriptionK02288 99.80%
  • Packaging10mg
  • Price$162
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3395
  • Product descriptionK02288 99.80%
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003498
  • Product descriptionK02288 98+%
  • Packaging50mg
  • Price$461
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7742
  • Product descriptionK02288 >98%
  • Packaging250mg
  • Price$800
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y1876 K02288 10mg $243 2021-12-16 Buy
AK Scientific Y1876 K02288 50mg $771 2021-12-16 Buy
Ambeed A151373 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% 5mg $50 2021-12-16 Buy
Ambeed A151373 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% 10mg $65 2021-12-16 Buy
Ambeed A151373 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol 98+% 50mg $110 2021-12-16 Buy
ApexBio Technology B2286 K02288 10mM(in 1mL DMSO) $149 2021-12-16 Buy
ApexBio Technology B2286 K02288 50mg $450 2021-12-16 Buy
Cayman Chemical 16678 K02288 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 16678 K02288 ≥98% 5mg $134 2024-03-01 Buy
Cayman Chemical 16678 K02288 ≥98% 10mg $231 2024-03-01 Buy
Cayman Chemical 16678 K02288 ≥98% 50mg $793 2024-03-01 Buy
Chemenu CM249406 3-(6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol 98% 50mg $404 2021-12-16 Buy
ChemScene CS-3395 K02288 99.80% 10mg $162 2021-12-16 Buy
ChemScene CS-3395 K02288 99.80% 50mg $540 2021-12-16 Buy
Crysdot CD31003498 K02288 98+% 50mg $461 2021-12-16 Buy
DC Chemicals DC7742 K02288 >98% 250mg $800 2021-12-16 Buy

Properties

Melting point :201-203°C
Boiling point :522.2±50.0 °C(Predicted)
Density :1.232±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.33±0.10(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.

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