ChemicalBook >> CAS DataBase List >>K 02288

K 02288

CAS No.
1431985-92-0
Chemical Name:
K 02288
Synonyms
CS-1877;K 02288;K 02288a;LM-3151 K02288;K 02288(K 02288a);K 02288 USP/EP/BP;K02288;K 02288;K-02288;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
CBNumber:
CB12677546
Molecular Formula:
C20H20N2O4
Molecular Weight:
352.38
MDL Number:
MFCD26936347
MOL File:
1431985-92-0.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

K 02288 Properties

Melting point 201-203°C
Boiling point 522.2±50.0 °C(Predicted)
Density 1.232±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 9.33±0.10(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H318
Precautionary statements  P280-P301+P310+P330-P305+P351+P338+P310
RIDADR  UN 2811 6.1 / PGIII
HS Code  2933.39.9200
NFPA 704
0
3 0

K 02288 price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1307 K02288 >98% (HPLC) 1431985-92-0 5MG $156 2023-06-20 Buy
Sigma-Aldrich SML1307 K02288 >98% (HPLC) 1431985-92-0 25MG $618 2023-06-20 Buy
Cayman Chemical 16678 K02288 ≥98% 1431985-92-0 1mg $37 2024-03-01 Buy
Cayman Chemical 16678 K02288 ≥98% 1431985-92-0 5mg $134 2024-03-01 Buy
Cayman Chemical 16678 K02288 ≥98% 1431985-92-0 10mg $231 2024-03-01 Buy
Product number Packaging Price Buy
SML1307 5MG $156 Buy
SML1307 25MG $618 Buy
16678 1mg $37 Buy
16678 5mg $134 Buy
16678 10mg $231 Buy

K 02288 Chemical Properties,Uses,Production

Description

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.

Uses

K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.

General Description

K02288 is a 2-aminopyridine compound.

Biochem/physiol Actions

K02288 is functionally similar to dorsomorphin, which is known to be the first small-molecule for BMP signaling inhibition.BMP signalling is associated with many important physiological processes. It acts a central regulator of developmental processes such as organogenesis, gastrulation, mesoderm induction and endochondral bone formation. BMP signals are also related to diseases including pulmonary hypertension, juvenile polyposis syndrome, fibrodysplasia ossificans progressiva and hereditary hemorrhagic telangiectasia syndrome. BMP signaling inhibition might serve as a tool to study its role in other biological processes.

storage

Store at -20°C

References

[1] sanvitale ce, kerr g, chaikuad a, ramel mc, mohedas ah, reichert s, wang y, triffitt jt, cuny gd, yu pb, hill cs, bullock an. a new class of small molecule inhibitor of bmp signaling. plos one. 2013 apr 30;8(4):e62721.

K 02288 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 98)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32956 60
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22785 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9984 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
+86-18341751992 +86-15382112998 757984502@qq.com China 892 58

K 02288 Spectrum

LM-3151 K02288 K 02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]- K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol K 02288(K 02288a) K 02288a K 02288 USP/EP/BP 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]- CS-1877 K02288;K 02288;K-02288 1431985-92-0 Inhibitors