K 02288
|
|
- CAS-Nr.
- 1431985-92-0
- Englisch Name:
- K 02288
- Synonyma:
- CS-1877;K 02288;K 02288a;LM-3151
K02288;K 02288(K 02288a);K 02288 USP/EP/BP;K02288;K 02288;K-02288;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
- CBNumber:
- CB12677546
- Summenformel:
- C20H20N2O4
- Molgewicht:
- 352.38
- MOL-Datei:
- 1431985-92-0.mol
|
K 02288 Eigenschaften
- Schmelzpunkt:
- 201-203°C
- Siedepunkt:
- 522.2±50.0 °C(Predicted)
- Dichte
- 1.232±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.33±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
K 02288 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC
50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC
50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation
in vitro (IC
50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.
Verwenden
K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.
Allgemeine Beschreibung
K02288 is a 2-aminopyridine compound.
K 02288 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
K 02288 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 97)Lieferanten
- LM-3151
K02288
- K 02288
- 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
- K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
- K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
- K 02288(K 02288a)
- K 02288a
- K 02288 USP/EP/BP
- 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol
- Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
- CS-1877
- K02288;K 02288;K-02288
- 1431985-92-0
- Inhibitors