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K 02288

K 02288 Struktur
1431985-92-0
CAS-Nr.
1431985-92-0
Englisch Name:
K 02288
Synonyma:
CS-1877;K 02288;K 02288a;LM-3151 K02288;K 02288(K 02288a);K 02288 USP/EP/BP;K02288;K 02288;K-02288;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
CBNumber:
CB12677546
Summenformel:
C20H20N2O4
Molgewicht:
352.38
MOL-Datei:
1431985-92-0.mol
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K 02288 Eigenschaften

Schmelzpunkt:
201-203°C
Siedepunkt:
522.2±50.0 °C(Predicted)
Dichte
1.232±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
pka
9.33±0.10(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  UN 2811 6.1 / PGIII
HS Code  2933.39.9200
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H318 Verursacht schwere Augenschäden. Schwere Augenschädigung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

K 02288 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Activation of bone morphogenetic protein (BMP) type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. K02288 is a 2-aminopyridine-based inhibitor of ALK1 and ALK2 with IC50 values of 1.8 and 1.1 nM, respectively. It is less selective for ALK3, 4, 5, and 6 subtypes and the type II BMP receptor ActRIIA, demonstrating IC50 values of 34.4, 302, 321, 6.4, and 220 nM, respectively. K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC50 = 100 nM) without affecting TGF-β signaling. Furthermore, at 8-10 μM, K02288 has been used to induce the dorsalization of zebrafish embryos. Through specific inhibition of BMP signaling, this compound can be used to research stem cell biology and disease models of musculoskeletal dysplasia and cancer.

Verwenden

K02288 is a potent and selective type 1 BMP (bone morphogenetic protein) receptor inhibitor with in vitro activity against ALK-2 (activin receptor-like kinase-2) at low nanomolar concentrations. K02288 also inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos.

Allgemeine Beschreibung

K02288 is a 2-aminopyridine compound.

K 02288 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

K 02288 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 97)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32836 60
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28180 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 24295 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896
 cbc@coresyn.com China 9991 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
  • LM-3151 K02288
  • K 02288
  • 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
  • K 02288 Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
  • K02288 3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
  • K 02288(K 02288a)
  • K 02288a
  • K 02288 USP/EP/BP
  • 3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol
  • Phenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
  • CS-1877
  • K02288;K 02288;K-02288
  • 1431985-92-0
  • Inhibitors
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