K-252A
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- $57 - $3800
- Product name: K-252A
- CAS: 99533-80-9
- MF: C27H21N3O5
- MW: 467.47
- EINECS:640-127-4
- MDL Number:MFCD09878276
- Synonyms:(9-alpha,10-beta,12-alpha)-este ;[9S,(+)]-2,3,9,10,11,12-Hexahydro-10α-hydroxy-9-methyl-1-oxo-9β,12β-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester;9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-;9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-;(9α,10β,12α)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-Methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid Methyl ester;K 252a(SF 2370);2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-0-carboxylicacimethyl ;9,1-epoxy-1h-diindolo(1,2,3-fg:3’,2’,1’-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1
15 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Alfa Aesar
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- TRC
Package
- 100UG-F
- 100μg
- 0.5mg
- 1mg
- 5mg
- 50mg
- 200μL
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0019-C100
- Product descriptionK-252a ≥98%(HPLC)
- Packaging100μg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ61687
- Product descriptionProtein Kinase Inhibitor
- Packaging1mg
- Price$297
- Updated2023-06-20
- Buy
- ManufacturerApexBio Technology
- Product numberB6828
- Product descriptionK252a
- Packaging1mg
- Price$520
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6828
- Product descriptionK252a
- Packaging5mg
- Price$1559
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11338
- Product descriptionK252a ≥98%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11338
- Product descriptionK252a
- Packaging5mg
- Price$208
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0014825
- Product descriptionK-252a 99.45%
- Packaging1mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0014825
- Product descriptionK-252a 99.45%
- Packaging5mg
- Price$990
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number05288
- Product descriptionK-252a fromNocardiopsissp.
- Packaging100μg
- Price$160
- Updated2023-01-07
- Buy
- ManufacturerSigma-Aldrich
- Product number05288
- Product descriptionK-252a from Nocardiopsis sp.
- Packaging100UG-F
- Price$171
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberK2015
- Product descriptionK-252a ReadyMadeSolution,fromNonomuraealongicatena,>98%
- Packaging200μL
- Price$223
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberK1639
- Product descriptionK-252a fromNonomuraealongicatena,≥98%(HPLC)
- Packaging100μg
- Price$225
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number82497
- Product descriptionK-252a from Nocardiopsis sp., ≥96.0% (HPLC)
- Packaging1mg
- Price$3800
- Updated2023-01-07
- Buy
- ManufacturerTRC
- Product numberK000500
- Product descriptionK252a
- Packaging0.5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberK000500
- Product descriptionK252a
- Packaging50mg
- Price$1390
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CN2-0019-C100 | K-252a ≥98%(HPLC) | 100μg | $60 | 2021-12-16 | Buy |
| Alfa Aesar | J61687 | Protein Kinase Inhibitor | 1mg | $297 | 2023-06-20 | Buy |
| ApexBio Technology | B6828 | K252a | 1mg | $520 | 2021-12-16 | Buy |
| ApexBio Technology | B6828 | K252a | 5mg | $1559 | 2021-12-16 | Buy |
| Cayman Chemical | 11338 | K252a ≥98% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 11338 | K252a | 5mg | $208 | 2024-03-01 | Buy |
| ChemScene | CS-0014825 | K-252a 99.45% | 1mg | $330 | 2021-12-16 | Buy |
| ChemScene | CS-0014825 | K-252a 99.45% | 5mg | $990 | 2021-12-16 | Buy |
| Sigma-Aldrich | 05288 | K-252a fromNocardiopsissp. | 100μg | $160 | 2023-01-07 | Buy |
| Sigma-Aldrich | 05288 | K-252a from Nocardiopsis sp. | 100UG-F | $171 | 2024-03-01 | Buy |
| Sigma-Aldrich | K2015 | K-252a ReadyMadeSolution,fromNonomuraealongicatena,>98% | 200μL | $223 | 2024-03-01 | Buy |
| Sigma-Aldrich | K1639 | K-252a fromNonomuraealongicatena,≥98%(HPLC) | 100μg | $225 | 2024-03-01 | Buy |
| Sigma-Aldrich | 82497 | K-252a from Nocardiopsis sp., ≥96.0% (HPLC) | 1mg | $3800 | 2023-01-07 | Buy |
| TRC | K000500 | K252a | 0.5mg | $95 | 2021-12-16 | Buy |
| TRC | K000500 | K252a | 50mg | $1390 | 2021-12-16 | Buy |
Properties
Melting point :262-273℃ (decomposition) (methanol )
Boiling point :685.3±55.0 °C(Predicted)
Density :1.68
Flash point :87℃
storage temp. :-20°C
solubility :DMF: 1 mg/mL
pka :11.95±0.40(Predicted)
form :Lyophilized solid.
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Boiling point :685.3±55.0 °C(Predicted)
Density :1.68
Flash point :87℃
storage temp. :-20°C
solubility :DMF: 1 mg/mL
pka :11.95±0.40(Predicted)
form :Lyophilized solid.
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.Related product price
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