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ChemicalBook >> CAS DataBase List >> KML-29

KML-29

KML-29 price.
  • $60 - $2400
  • Product name: KML-29
  • CAS: 1380424-42-9
  • MF: C24H21F6NO7
  • MW: 549.42
  • EINECS:
  • MDL Number:MFCD22987957
  • Synonyms:KML-29;KML29;KML-29;KML 29;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;CS-2396;KML29 (KML-29);1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;LPS,allodynia,Monoacylglycerol lipase,KML29,MAGL,inhibit,2-AG,Inhibitor,HFIP,KML 29,KML-29
24 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5mg
  • 10mg
  • 50
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number0860DV
  • Product descriptionCID71656212
  • Packaging10mg
  • Price$222
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5745
  • Product descriptionKML29
  • Packaging5mg
  • Price$103
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5745
  • Product descriptionKML29
  • Packaging10mg
  • Price$166
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5745
  • Product descriptionKML29
  • Packaging50mg
  • Price$655
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5745
  • Product descriptionKML29
  • Packaging100mg
  • Price$1188
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11777
  • Product descriptionKML29 ≥98%
  • Packaging5mg
  • Price$61
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11777
  • Product descriptionKML29 ≥98%
  • Packaging10mg
  • Price$112
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11777
  • Product descriptionKML29 ≥98%
  • Packaging50mg
  • Price$468
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11777
  • Product descriptionKML29 ≥98%
  • Packaging100mg
  • Price$816
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM249147
  • Product description1,1,1,3,3,3-Hexafluoropropan-2-yl4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 98%
  • Packaging100mg
  • Price$521
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4992
  • Product descriptionKML29 99.21%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4992
  • Product descriptionKML29 99.21%
  • Packaging10mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4992
  • Product descriptionKML29 99.21%
  • Packaging50mg
  • Price$384
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-4992
  • Product descriptionKML29 99.21%
  • Packaging100mg
  • Price$696
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003685
  • Product descriptionKML29 98+%
  • Packaging50mg
  • Price$426
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10536
  • Product descriptionKML-29 >98%
  • Packaging100mg
  • Price$600
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0860DV CID71656212 10mg $222 2021-12-16 Buy
ApexBio Technology B5745 KML29 5mg $103 2021-12-16 Buy
ApexBio Technology B5745 KML29 10mg $166 2021-12-16 Buy
ApexBio Technology B5745 KML29 50mg $655 2021-12-16 Buy
ApexBio Technology B5745 KML29 100mg $1188 2021-12-16 Buy
Cayman Chemical 11777 KML29 ≥98% 5mg $61 2024-03-01 Buy
Cayman Chemical 11777 KML29 ≥98% 10mg $112 2024-03-01 Buy
Cayman Chemical 11777 KML29 ≥98% 50mg $468 2024-03-01 Buy
Cayman Chemical 11777 KML29 ≥98% 100mg $816 2024-03-01 Buy
Chemenu CM249147 1,1,1,3,3,3-Hexafluoropropan-2-yl4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 98% 100mg $521 2021-12-16 Buy
ChemScene CS-4992 KML29 99.21% 5mg $60 2021-12-16 Buy
ChemScene CS-4992 KML29 99.21% 10mg $96 2021-12-16 Buy
ChemScene CS-4992 KML29 99.21% 50mg $384 2021-12-16 Buy
ChemScene CS-4992 KML29 99.21% 100mg $696 2021-12-16 Buy
Crysdot CD31003685 KML29 98+% 50mg $426 2021-12-16 Buy
DC Chemicals DC10536 KML-29 >98% 100mg $600 2021-12-16 Buy

Properties

Melting point :204-206°C
Boiling point :554.8±50.0 °C(Predicted)
Density :1.511±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
pka :13.32±0.29(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). At 5-20 mg/kg, KML29 dose-dependently blocks mouse brain MAGL activity in vivo, without any measurable effect on FAAH activity. As a second generation MAGL inhibitor, KML29 supersedes the low-level cross-reactivity that JZL 184 displays for FAAH yet still maintains comparable potency to its parent compound.