LRRK2-IN-1
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- $33 - $7200
- Product name: LRRK2-IN-1
- CAS: 1234480-84-2
- MF: C31H38N8O3
- MW: 570.69
- EINECS:
- MDL Number:MFCD22683805
- Synonyms:5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;LRRK2-IN-1;LRRK2-TN-1;2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl-;CS-642;LRRK2-IN-1; LRRK2 INHIBITOR;LRRK2 inhibitor;6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-
21 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 5mg
- 1MG
- 50
- 10MG
- 2x25mg
- 50mg
- 100MG
- 250mg
- 5g
- 10mM(in 1mL DMSO)
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001364
- Product descriptionLRRK2-IN-1 95.00%
- Packaging1MG
- Price$750.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001364
- Product descriptionLRRK2-IN-1 95.00%
- Packaging10MG
- Price$981.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001364
- Product descriptionLRRK2-IN-1 95.00%
- Packaging100MG
- Price$2252.25
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3558
- Product descriptionLRRK2-IN-1
- Packaging10mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3558
- Product descriptionLRRK2-IN-1
- Packaging10mM(in 1mL DMSO)
- Price$127
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2493
- Product descriptionLRRK2-IN-1 99%
- Packaging2x25mg
- Price$539
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18094
- Product descriptionLRRK2-IN-1 ≥95%
- Packaging1mg
- Price$33
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18094
- Product descriptionLRRK2-IN-1 ≥95%
- Packaging5mg
- Price$112
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18094
- Product descriptionLRRK2-IN-1 ≥95%
- Packaging10mg
- Price$208
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31004151
- Product descriptionLRRK-2IN1 98+%
- Packaging50mg
- Price$374
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004151
- Product descriptionLRRK-2IN1 98+%
- Packaging100mg
- Price$668
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8237
- Product descriptionLRRK2-IN-1 >98%
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8237
- Product descriptionLRRK2-IN-1 >98%
- Packaging250mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number132619
- Product description2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one 97%
- Packaging100mg
- Price$3780
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number132619
- Product description2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one 97%
- Packaging5g
- Price$7200
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number438193
- Product descriptionLRRK2-IN-1 LRRK2-IN-1 primarily used in Inhibition.
- Packaging5MG
- Price$182
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | KIN0001364 | LRRK2-IN-1 95.00% | 1MG | $750.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001364 | LRRK2-IN-1 95.00% | 10MG | $981.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001364 | LRRK2-IN-1 95.00% | 100MG | $2252.25 | 2021-12-16 | Buy |
| ApexBio Technology | A3558 | LRRK2-IN-1 | 10mg | $85 | 2021-12-16 | Buy |
| ApexBio Technology | A3558 | LRRK2-IN-1 | 10mM(in 1mL DMSO) | $127 | 2021-12-16 | Buy |
| Axon Medchem | Axon2493 | LRRK2-IN-1 99% | 2x25mg | $539 | 2021-12-16 | Buy |
| Cayman Chemical | 18094 | LRRK2-IN-1 ≥95% | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 18094 | LRRK2-IN-1 ≥95% | 5mg | $112 | 2024-03-01 | Buy |
| Cayman Chemical | 18094 | LRRK2-IN-1 ≥95% | 10mg | $208 | 2024-03-01 | Buy |
| Crysdot | CD31004151 | LRRK-2IN1 98+% | 50mg | $374 | 2021-12-16 | Buy |
| Crysdot | CD31004151 | LRRK-2IN1 98+% | 100mg | $668 | 2021-12-16 | Buy |
| DC Chemicals | DC8237 | LRRK2-IN-1 >98% | 100mg | $500 | 2021-12-16 | Buy |
| DC Chemicals | DC8237 | LRRK2-IN-1 >98% | 250mg | $900 | 2021-12-16 | Buy |
| Matrix Scientific | 132619 | 2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one 97% | 100mg | $3780 | 2021-12-16 | Buy |
| Matrix Scientific | 132619 | 2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one 97% | 5g | $7200 | 2021-12-16 | Buy |
| Sigma-Aldrich | 438193 | LRRK2-IN-1 LRRK2-IN-1 primarily used in Inhibition. | 5MG | $182 | 2024-03-01 | Buy |
Properties
Boiling point :787.8±70.0 °C(Predicted)
Density :1.278
storage temp. :Store at -20°C
solubility :≥28.55 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
form :solid
pka :8.14±0.42(Predicted)
color :Light yellow to yellow
Density :1.278
storage temp. :Store at -20°C
solubility :≥28.55 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
form :solid
pka :8.14±0.42(Predicted)
color :Light yellow to yellow
Safety Information
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Description
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. LRRK2-IN-1 is a potent inhibitor of LRRK2 that inhibits both wild-type and G2019S mutant LRRK2 (IC50s = 13 and 6 nM, respectively). It is selective for LRRK2 over a large panel of other kinases. LRRK2-IN-1 treatment causes dephosphorylation of LRRK2, leading to its dissociation from 14-3-3 proteins, ubiquitination, and degradation. Inhibitors of LRRK2, including LRRK2-IN-1, stimulate macroautophagy in H4 neuroglioma cells.Suppliers and manufacturers
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