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LRRK2-IN-1

LRRK2-IN-1 Structure
LRRK2-IN-1 structure
CAS No.
1234480-84-2
Chemical Name:
LRRK2-IN-1
Synonyms
CS-642;NSC7001;NSC 7001;NSC-7001;LRRK2-TN-1;LRRK2-IN-1;LRRK2 inhibitor;LRRK2-IN-1 USP/EP/BP;LRRK2-IN-1; LRRK2 INHIBITOR;2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl-
CBNumber:
CB12534670
Molecular Formula:
C31H38N8O3
Molecular Weight:
570.69
MDL Number:
MFCD22683805
MOL File:
1234480-84-2.mol
Last updated:2023-09-20 16:43:00
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LRRK2-IN-1 Properties

Boiling point 787.8±70.0 °C(Predicted)
Density 1.278
storage temp. Store at -20°C
solubility ≥28.55 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
form solid
pka 8.14±0.42(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

LRRK2-IN-1 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 438193 LRRK2-IN-1 LRRK2-IN-1 primarily used in Inhibition. 5MG $182 2024-03-01 Buy
Cayman Chemical 18094 LRRK2-IN-1 ≥95% 1234480-84-2 1mg $33 2024-03-01 Buy
Cayman Chemical 18094 LRRK2-IN-1 ≥95% 1234480-84-2 5mg $112 2024-03-01 Buy
Cayman Chemical 18094 LRRK2-IN-1 ≥95% 1234480-84-2 10mg $208 2024-03-01 Buy
Tocris 4273 LRRK2-IN-1 ≥98%(HPLC) 1234480-84-2 10 $292 2021-12-16 Buy
Product number Packaging Price Buy
438193 5MG $182 Buy
18094 1mg $33 Buy
18094 5mg $112 Buy
18094 10mg $208 Buy
4273 10 $292 Buy

LRRK2-IN-1 Chemical Properties,Uses,Production

Description

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson''s disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. LRRK2-IN-1 is a potent inhibitor of LRRK2 that inhibits both wild-type and G2019S mutant LRRK2 (IC50s = 13 and 6 nM, respectively). It is selective for LRRK2 over a large panel of other kinases. LRRK2-IN-1 treatment causes dephosphorylation of LRRK2, leading to its dissociation from 14-3-3 proteins, ubiquitination, and degradation. Inhibitors of LRRK2, including LRRK2-IN-1, stimulate macroautophagy in H4 neuroglioma cells.

Uses

LRRK2-IN-1 is a benzodiazepine based derivative and is known as a selective inhibitor of the Parkinson''s disease kinase LRRK2.

Definition

ChEBI: LRRK2-IN-1 is a member of the class of pyrimidobenzodiazepines that is 5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one carrying at C-2 on the pyrimidine ring a 4-[(4-methylpiperazin-1-yl)piperidine-1-carbonyl]-2-methoxyanilino substituent. It is an inhibitor of the Parkinson's disease kinase LRRK2. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an antineoplastic agent. It is a N-acylpiperidine, a N-alkylpiperazine, an aromatic ether, a pyrimidobenzodiazepine, an aromatic amine, a secondary amino compound and a tertiary amino compound.

storage

Store at -20°C

LRRK2-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

LRRK2-IN-1 Suppliers

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49391 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 26823 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10522 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19915 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Hubei Jusheng Technology Co.,Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nextpeptide Inc 		58

View Lastest Price from LRRK2-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LRRK2-IN-1 pictures 2019-12-24 LRRK2-IN-1
1234480-84-2
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co
  • LRRK2-IN-1 pictures
  • LRRK2-IN-1
    1234480-84-2
  • US $1.00 / KG
  • Min98% HPLC
  • Career Henan Chemical Co

LRRK2-IN-1 Spectrum

LRRK2-IN-1(1234480-84-2)MSLRRK2-IN-1(1234480-84-2)1HNMR

1234480-84-2(LRRK2-IN-1)Related Search:

Lrrk2 Inhibitor
5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one LRRK2-IN-1 LRRK2-TN-1 2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl- CS-642 LRRK2-IN-1; LRRK2 INHIBITOR LRRK2 inhibitor 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl- LRRK2-IN-1 USP/EP/BP 2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)-amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one NSC 7001 NSC7001 NSC-7001 1234480-84-2 C31H38N8O3 Inhibitors