Linifanib (ABT-869)
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- $40 - $2245.7
- Product name: Linifanib (ABT-869)
- CAS: 796967-16-3
- MF: C21H18FN5O
- MW: 375.4
- EINECS:
- MDL Number:MFCD11840918
- Synonyms:1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea;Linifanib;N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea;N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea;Urea, N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)-;ABT-869 5.2G;AL-39324;RG3635
33 prices
Selected condition：
Brand
- Adipogen Life Sciences
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1MG
- 5MG
- 10mg
- 25mg
- 50MG
- 100mg
- 200mg
- 500mg
- 10mM(in 1mL DMSO)
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1002-M100
- Product descriptionLinifanib ≥95%
- Packaging100mg
- Price$1026
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000538
- Product descriptionABT-869 95.00%
- Packaging1MG
- Price$203.7
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000538
- Product descriptionABT-869 95.00%
- Packaging5MG
- Price$816.75
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000538
- Product descriptionABT-869 95.00%
- Packaging50MG
- Price$2194.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2949
- Product descriptionLinifanib(ABT-869)
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2949
- Product descriptionLinifanib(ABT-869)
- Packaging10mM(in 1mL DMSO)
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2949
- Product descriptionLinifanib(ABT-869)
- Packaging25mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2949
- Product descriptionLinifanib(ABT-869)
- Packaging100mg
- Price$630
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberPC402063
- Product description1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
- Packaging100mg
- Price$279
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberPC402063
- Product description1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
- Packaging250mg
- Price$557
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberPC402063
- Product description1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
- Packaging1g
- Price$1378
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60453
- Product descriptionLinifanib(ABT-869) ≥98%
- Packaging10mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154718
- Product descriptionLinifanib (ABT-869) >98%
- Packaging100mg
- Price$542.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154718
- Product descriptionLinifanib (ABT-869) >98%
- Packaging250mg
- Price$1060.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154718
- Product descriptionLinifanib (ABT-869) >98%
- Packaging1g
- Price$2245.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13653
- Product descriptionABT-869 ≥98%
- Packaging1mg
- Price$40
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1002-M100 | Linifanib ≥95% | 100mg | $1026 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000538 | ABT-869 95.00% | 1MG | $203.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000538 | ABT-869 95.00% | 5MG | $816.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000538 | ABT-869 95.00% | 50MG | $2194.5 | 2021-12-16 | Buy |
| ApexBio Technology | A2949 | Linifanib(ABT-869) | 5mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A2949 | Linifanib(ABT-869) | 10mM(in 1mL DMSO) | $125 | 2021-12-16 | Buy |
| ApexBio Technology | A2949 | Linifanib(ABT-869) | 25mg | $240 | 2021-12-16 | Buy |
| ApexBio Technology | A2949 | Linifanib(ABT-869) | 100mg | $630 | 2021-12-16 | Buy |
| Apolloscientific | PC402063 | 1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea | 100mg | $279 | 2021-12-16 | Buy |
| Apolloscientific | PC402063 | 1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea | 250mg | $557 | 2021-12-16 | Buy |
| Apolloscientific | PC402063 | 1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea | 1g | $1378 | 2021-12-16 | Buy |
| Arctom | CFN60453 | Linifanib(ABT-869) ≥98% | 10mg | $168 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154718 | Linifanib (ABT-869) >98% | 100mg | $542.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154718 | Linifanib (ABT-869) >98% | 250mg | $1060.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154718 | Linifanib (ABT-869) >98% | 1g | $2245.7 | 2021-12-16 | Buy |
| Cayman Chemical | 13653 | ABT-869 ≥98% | 1mg | $40 | 2024-03-01 | Buy |
Properties
Melting point :180-183°C (dec.)
Boiling point :542.2±50.0 °C(Predicted)
Density :1.424
storage temp. :-20°C Freezer
solubility :DMSO, Methanol
pka :13.30±0.70(Predicted)
form :Brown powder.
color :Beige
Boiling point :542.2±50.0 °C(Predicted)
Density :1.424
storage temp. :-20°C Freezer
solubility :DMSO, Methanol
pka :13.30±0.70(Predicted)
form :Brown powder.
color :Beige
Safety Information
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Description
Receptor tyrosine kinases (RTKs) mediate critical signaling transduction pathways important for cell survival, growth, and differentiation. Whereas aberrant tyrosine kinase signaling is correlated with the progression of various cancers, RTK inhibitors are useful as cancer therapy agents. ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families (e.g., KDR, FLT1, FLT3, FLT4, CSF-1R, and KIT) demonstrating IC50 values ranging from 4-190 nM. ABT-869 shows little activity against unrelated RTKs, cytoplasmic tyrosine kinases, or Ser/Thr kinases (IC50s > 1 μM). ABT-869 inhibits proliferation in MV-4-11 and MOLM-13 cells (acute myeloid leukemia cell lines harboring RTK mutations; IC50s = 4 and 6 nM, respectively), inducing apoptosis as evidenced by an increased sub-G0/G1 phase cell population, caspase activation, and PARP cleavage. In murine xenograft models, as well as in a phase 1 clinical trial, ABT-869 demonstrated respectable efficacy in solid tumors including lung and hepatocellular carcinomas.More related product prices
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