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ChemicalBook >> CAS DataBase List >> Cediranib

Cediranib

Cediranib price.
  • $24 - $2975
  • Product name: Cediranib
  • CAS: 288383-20-0
  • MF: C25H27FN4O3
  • MW: 450.51
  • EINECS:670-946-2
  • MDL Number:MFCD09954115
  • Synonyms:Cediranib ;4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline;Cadiranib (AZD2171);Cediranib(AZD2171);AZD2171;Recentin;Cadiranib;Cediranib R
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  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
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  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberX2636
  • Product descriptionCediranib
  • Packaging1mg
  • Price$24
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA368855
  • Product description4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 98+%
  • Packaging50mg
  • Price$183
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA368855
  • Product description4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 98+%
  • Packaging10mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA368855
  • Product description4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 98+%
  • Packaging5mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000551
  • Product descriptionCEDIRANIB 95.00%
  • Packaging25MG
  • Price$883.11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000551
  • Product descriptionCEDIRANIB 95.00%
  • Packaging10MG
  • Price$781.24
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000551
  • Product descriptionCEDIRANIB 95.00%
  • Packaging5MG
  • Price$530
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1882
  • Product descriptionCediranib(AZD217)
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1882
  • Product descriptionCediranib(AZD217)
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1882
  • Product descriptionCediranib(AZD217)
  • Packaging25mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1882
  • Product descriptionCediranib(AZD217)
  • Packaging100mg
  • Price$470
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2627
  • Product descriptionCediranib
  • Packaging5mg
  • Price$49
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2627
  • Product descriptionCediranib
  • Packaging10mg
  • Price$69
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2627
  • Product descriptionCediranib
  • Packaging25mg
  • Price$129
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2627
  • Product descriptionCediranib
  • Packaging100mg
  • Price$295
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2627
  • Product descriptionCediranib
  • Packaging1g
  • Price$975
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X2636 Cediranib 1mg $24 2021-12-16 Buy
Ambeed A368855 4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 98+% 50mg $183 2021-12-16 Buy
Ambeed A368855 4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 98+% 10mg $132 2021-12-16 Buy
Ambeed A368855 4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 98+% 5mg $88 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000551 CEDIRANIB 95.00% 25MG $883.11 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000551 CEDIRANIB 95.00% 10MG $781.24 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000551 CEDIRANIB 95.00% 5MG $530 2021-12-16 Buy
ApexBio Technology A1882 Cediranib(AZD217) 5mg $75 2021-12-16 Buy
ApexBio Technology A1882 Cediranib(AZD217) 10mM(in 1mL DMSO) $80 2021-12-16 Buy
ApexBio Technology A1882 Cediranib(AZD217) 25mg $180 2021-12-16 Buy
ApexBio Technology A1882 Cediranib(AZD217) 100mg $470 2021-12-16 Buy
AvaChem 2627 Cediranib 5mg $49 2021-12-16 Buy
AvaChem 2627 Cediranib 10mg $69 2021-12-16 Buy
AvaChem 2627 Cediranib 25mg $129 2021-12-16 Buy
AvaChem 2627 Cediranib 100mg $295 2021-12-16 Buy
AvaChem 2627 Cediranib 1g $975 2021-12-16 Buy

Properties

Melting point :135-138°C
Boiling point :626.6±55.0 °C(Predicted)
Density :1.285
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :16.14±0.30(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Receptors for VEGF have central roles in vasculogenesis and angiogenesis and thus serve as targets for cancer therapy. Cediranib is a potent inhibitor of VEGF receptor tyrosine kinases, including VEGFR1, 2, and 3 (IC50s = 5, 1, and 3 nM, respectively). It also potently inhibits a variety of other receptor and non-receptor tyrosine kinases, including several in the platelet-derived growth factor, fibroblast growth factor, and endothelial growth factor receptor families. Cediranib blocks tubule formation by human umbilical vein endothelial cells in vitro and prevents angiogenesis as well as xenograft tumor growth in vivo. Because of these effects, cediranib has potential use in a range of cancers.

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