ML-179
|
- $44 - $2050
- Product name: ML-179
- CAS: 1883548-87-5
- MF: C21H25F3N4O2
- MW: 422.44
- EINECS:
- MDL Number:MFCD25563255
- Synonyms:ML-179;3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione;2,4(1H,3H)-Pyrimidinedione, 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-;3-cyclohexyl-6-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione;C57Bl6 mice,inhibit,SAA4,ER-negative breast cancer,probe compounds,ML 179,MCF-7,SAA1,Inhibitor,ML179,inverse
11 prices
Selected condition：
Brand
- Cayman Chemical
- DC Chemicals
- Medical Isotopes, Inc.
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 50
- 25mg
- 100mg
- 250mg
- 1g
- ManufacturerCayman Chemical
- Product number15180
- Product descriptionML-179 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15180
- Product descriptionML-179 ≥98%
- Packaging5mg
- Price$118
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15180
- Product descriptionML-179 ≥98%
- Packaging10mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15180
- Product descriptionML-179 ≥98%
- Packaging25mg
- Price$374
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC42664
- Product descriptionML-179 >98%
- Packaging250mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC42664
- Product descriptionML-179 >98%
- Packaging1g
- Price$1600
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number41650
- Product descriptionML-179
- Packaging100mg
- Price$2050
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4957
- Product descriptionML179 ≥99%(HPLC)
- Packaging10
- Price$215
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number4957
- Product descriptionML179 ≥99%(HPLC)
- Packaging50
- Price$901
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberM425080
- Product descriptionML-179
- Packaging10mg
- Price$165
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number255849
- Product descriptionML 179
- Packaging10mg
- Price$475
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 15180 | ML-179 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 15180 | ML-179 ≥98% | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 15180 | ML-179 ≥98% | 10mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 15180 | ML-179 ≥98% | 25mg | $374 | 2024-03-01 | Buy |
| DC Chemicals | DC42664 | ML-179 >98% | 250mg | $800 | 2021-12-16 | Buy |
| DC Chemicals | DC42664 | ML-179 >98% | 1g | $1600 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 41650 | ML-179 | 100mg | $2050 | 2021-12-16 | Buy |
| Tocris | 4957 | ML179 ≥99%(HPLC) | 10 | $215 | 2021-12-16 | Buy |
| Tocris | 4957 | ML179 ≥99%(HPLC) | 50 | $901 | 2021-12-16 | Buy |
| TRC | M425080 | ML-179 | 10mg | $165 | 2021-12-16 | Buy |
| Usbiological | 255849 | ML 179 | 10mg | $475 | 2021-12-16 | Buy |
Properties
Density :1.329±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: 10 mg/ml
form :A crystalline solid
pka :9.37±0.40(Predicted)
color :White to off-white
InChI :InChI=1S/C21H25F3N4O2/c22-21(23,24)15-5-4-8-17(13-15)26-9-11-27(12-10-26)18-14-19(29)28(20(30)25-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,25,30)
InChIKey :MFABFKUNLDYKGH-UHFFFAOYSA-N
SMILES :C1(=O)NC(N2CCN(C3=CC=CC(C(F)(F)F)=C3)CC2)=CC(=O)N1C1CCCCC1
storage temp. :Store at -20°C
solubility :DMSO: 10 mg/ml
form :A crystalline solid
pka :9.37±0.40(Predicted)
color :White to off-white
InChI :InChI=1S/C21H25F3N4O2/c22-21(23,24)15-5-4-8-17(13-15)26-9-11-27(12-10-26)18-14-19(29)28(20(30)25-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,25,30)
InChIKey :MFABFKUNLDYKGH-UHFFFAOYSA-N
SMILES :C1(=O)NC(N2CCN(C3=CC=CC(C(F)(F)F)=C3)CC2)=CC(=O)N1C1CCCCC1
Safety Information
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Description
ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.12 μM).Suppliers and manufacturers
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