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ChemicalBook >> CAS DataBase List >> MONASTROL

MONASTROL

MONASTROL price.
  • $75 - $1760
  • Product name: MONASTROL
  • CAS: 254753-54-3
  • MF: C14H16N2O3S
  • MW: 292.35
  • EINECS:
  • MDL Number:MFCD11978057
  • Synonyms:4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDRO-4H-PYRIMIDIN-5-CARBOXYLIC ACID ETHYL ESTER;6-METHYL-4-(3-HYDROXYPHENYL)-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE;1,2,3,4-TETRAHYDRO-4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-5-PYRIMIDINECARBOXYLIC ACID, ETHYL ESTER;Monastrol - CAS 254753-54-3 - Calbiochem;CS-2432;5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-, ethyl ester, (4S)-;O-(4-Hydroxy-3-iodophenyl)-3;Monastrol(b)
7 prices
Selected condition:
Brand
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5mg
  • 25mg
  • 002
  • ManufacturerDC Chemicals
  • Product number026091
  • Product descriptionMonastrol
  • Packaging002
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number12387
  • Product descriptionMonastrol
  • Packaging25mg
  • Price$1760
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberM8515
  • Product descriptionMonastrol ≥98% (HPLC), solid
  • Packaging5mg
  • Price$469
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number475879
  • Product descriptionMonastrol A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.
  • Packaging5mg
  • Price$373
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberM8515
  • Product descriptionMonastrol ≥98% (HPLC), solid
  • Packaging1mg
  • Price$138
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number475879
  • Product descriptionMonastrol A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.
  • Packaging1mg
  • Price$113
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberM505753
  • Product descriptionMonastrol
  • Packaging1mg
  • Price$75
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
DC Chemicals 026091 Monastrol 002 $950 2021-12-16 Buy
Medical Isotopes, Inc. 12387 Monastrol 25mg $1760 2021-12-16 Buy
Sigma-Aldrich M8515 Monastrol ≥98% (HPLC), solid 5mg $469 2024-03-01 Buy
Sigma-Aldrich 475879 Monastrol A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. 5mg $373 2024-03-01 Buy
Sigma-Aldrich M8515 Monastrol ≥98% (HPLC), solid 1mg $138 2024-03-01 Buy
Sigma-Aldrich 475879 Monastrol A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. 1mg $113 2024-03-01 Buy
TRC M505753 Monastrol 1mg $75 2021-12-16 Buy

Properties

Melting point :185-185.9 °C(lit.)
Boiling point :441.3±55.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 100 mg/mL
form :White solid
pka :9.63±0.10(Predicted)
color :white to off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference :254753-54-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Monastrol is a potent, cell-permeable, small molecule mitosis inhibitor that does not interact with tubulin. Monastrol arrests cells in mitosis and specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein required for mitotic spindle formation and maintenance (IC50 = 14 μM).

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