MP-A08
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- $33 - $1802
- Product name: MP-A08
- CAS: 219832-49-2
- MF: C27H25N3O4S2
- MW: 519.64
- EINECS:
- MDL Number:
- Synonyms:MP-A08;Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-;4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide;MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08
23 prices
Selected condition：
Brand
- AK Scientific
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
- TRC
Package
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number2209CC
- Product description4-Methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide
- Packaging25mg
- Price$538
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611453
- Product descriptionMP-A08
- Packaging5mg
- Price$569.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611453
- Product descriptionMP-A08
- Packaging10mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611453
- Product descriptionMP-A08
- Packaging50mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21903
- Product descriptionMP-A08 ≥98%
- Packaging1mg
- Price$33
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21903
- Product descriptionMP-A08 ≥98%
- Packaging5mg
- Price$96
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21903
- Product descriptionMP-A08 ≥98%
- Packaging10mg
- Price$176
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21903
- Product descriptionMP-A08 ≥98%
- Packaging25mg
- Price$396
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-5681
- Product descriptionMP-A08 >98.0%
- Packaging1mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5681
- Product descriptionMP-A08 >98.0%
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5681
- Product descriptionMP-A08 >98.0%
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5681
- Product descriptionMP-A08 >98.0%
- Packaging50mg
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5681
- Product descriptionMP-A08 >98.0%
- Packaging100mg
- Price$690
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002646
- Product descriptionMP-A08 98+%
- Packaging5mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002646
- Product descriptionMP-A08 98+%
- Packaging10mg
- Price$347
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002646
- Product descriptionMP-A08 98+%
- Packaging50mg
- Price$1042
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2209CC | 4-Methyl-N-[2-[[2-[(4-methylphenyl)sulfonylamino]phenyl]iminomethyl]phenyl]benzenesulfonamide | 25mg | $538 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611453 | MP-A08 | 5mg | $569.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611453 | MP-A08 | 10mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611453 | MP-A08 | 50mg | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 21903 | MP-A08 ≥98% | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 21903 | MP-A08 ≥98% | 5mg | $96 | 2024-03-01 | Buy |
| Cayman Chemical | 21903 | MP-A08 ≥98% | 10mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 21903 | MP-A08 ≥98% | 25mg | $396 | 2024-03-01 | Buy |
| ChemScene | CS-5681 | MP-A08 >98.0% | 1mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-5681 | MP-A08 >98.0% | 5mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-5681 | MP-A08 >98.0% | 10mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-5681 | MP-A08 >98.0% | 50mg | $390 | 2021-12-16 | Buy |
| ChemScene | CS-5681 | MP-A08 >98.0% | 100mg | $690 | 2021-12-16 | Buy |
| Crysdot | CD31002646 | MP-A08 98+% | 5mg | $243 | 2021-12-16 | Buy |
| Crysdot | CD31002646 | MP-A08 98+% | 10mg | $347 | 2021-12-16 | Buy |
| Crysdot | CD31002646 | MP-A08 98+% | 50mg | $1042 | 2021-12-16 | Buy |
Properties
Boiling point :717.1±70.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
solubility :DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
form :A crystalline solid
pka :7.88±0.10(Predicted)
color :Light yellow to yellow
Density :1.28±0.1 g/cm3(Predicted)
solubility :DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
form :A crystalline solid
pka :7.88±0.10(Predicted)
color :Light yellow to yellow
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
MP-A08 is an ATP-competitive inhibitor of sphingosine kinases SPHK1 and SPHK2 (Kis = 27 and 6.9 μM, respectively). It is selective for SPHK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; ) without inducing degradation of SPHK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide , C-20 ceramide , and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.Suppliers and manufacturers
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