MP-A08
- CAS No.
- 219832-49-2
- Chemical Name:
- MP-A08
- Synonyms
- MP-A08;MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide;4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide;Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-
- CBNumber:
- CB33133348
- Molecular Formula:
- C27H25N3O4S2
- Molecular Weight:
- 519.64
- MDL Number:
- MOL File:
- 219832-49-2.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
MP-A08 price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21903 | MP-A08 ≥98% | 219832-49-2 | 1mg | $33 | 2024-03-01 | Buy |
Cayman Chemical | 21903 | MP-A08 ≥98% | 219832-49-2 | 5mg | $96 | 2024-03-01 | Buy |
Cayman Chemical | 21903 | MP-A08 ≥98% | 219832-49-2 | 10mg | $176 | 2024-03-01 | Buy |
Cayman Chemical | 21903 | MP-A08 ≥98% | 219832-49-2 | 25mg | $396 | 2024-03-01 | Buy |
Tocris | 5803 | MPA08 | 219832-49-2 | 10 | $168 | 2021-12-16 | Buy |
MP-A08 Chemical Properties,Uses,Production
Description
MP-A08 is an ATP-competitive inhibitor of sphingosine kinases SPHK1 and SPHK2 (Kis = 27 and 6.9 μM, respectively). It is selective for SPHK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; ) without inducing degradation of SPHK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide , C-20 ceramide , and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.
Uses
NSC 122314 is selective ATP competitive sphingosine kinase 2 and 1 inhibitor. Also it induces mitochondrial-associated apoptosis.
Definition
ChEBI: MP-A08 is a sulfonamide that consists of two moieties of 4-methyl-N-phenylbenzenesulfonamide connected to each other at position 2 by an aldimine linker. It is a ATP-competitive inhibitor of sphingosine kinase that targets both SK1 and SK2 (Ki values of 27 muM and 6.9 muM, respectively) and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor and an EC 2.7.1.91 (sphingosine kinase) inhibitor. It is a sulfonamide, a member of toluenes and an aldimine.
storage
Store at -20°C
MP-A08 Preparation Products And Raw materials
Raw materials
Preparation Products
MP-A08 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3717 | 55 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29795 | 68 |
MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4992 | 55 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |