MP-A08
MP-A08 物理性質
- 沸点 :
- 717.1±70.0 °C(Predicted)
- 比重(密度) :
- 1.28±0.1 g/cm3(Predicted)
- 溶解性:
- DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
- 外見 :
- A crystalline solid
- 酸解離定数(Pka):
- 7.88±0.10(Predicted)
- 色:
- Light yellow to yellow
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
MP-A08 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
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更新時間 |
購入 |
MP-A08 化学特性,用途語,生産方法
説明
MP-A08 is an ATP-competitive inhibitor of sphingosine kinases SPHK1 and SPHK2 (K
is = 27 and 6.9 μM, respectively). It is selective for SPHK1/2 over a panel of 140 human protein kinases at concentrations up to 25 μM. MP-A08 (15 μM) reduces generation of cellular sphingosine-1-phosphate (S1P; ) without inducing degradation of SPHK1 in Jurkat cells. It induces a 3.7-, 3.5-, and 5.8-fold increase in C-18 ceramide , C-20 ceramide , and C20:1-ceramide levels, respectively, and dose-dependently activates the apoptosis-associated p38 and JNK pathways
in vitro. MP-A08 reduces proliferation of a variety of human cancer cell lines (EC
50s = 8-44.9 μM). MP-A08 also reduces tumor vasculature, as determined by CD31 staining, and volume as well as S1P protein levels in A549 human lung adenocarcinoma xenografts in mice.
使用
NSC 122314 is selective ATP competitive sphingosine kinase 2 and 1 inhibitor. Also it induces mitochondrial-associated apoptosis.
MP-A08 上流と下流の製品情報
原材料
準備製品
MP-A08 生産企業
Global( 39)Suppliers
- 219832-49-2
- MP-A08
- Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-
- 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
- 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide
- MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08