219832-49-2
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- CAS号:
- 219832-49-2
- 英文名:
- MP-A08
- 英文别名:
- MP-A08;MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide;4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide;4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide , MP-A08;Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-
- 中文名:
- 219832-49-2
- 中文别名:
- 化合物MP-A08;SK抑制剂(MP-A08);MP A08,ATP竞争性SPHK1和2抑制剂;4-甲基-N-(2-((2-((4-甲基苯基)磺酰胺基)亚苄基)氨基)苯基)苯磺酰胺
- CBNumber:
- CB33133348
- 分子式:
- C27H25N3O4S2
- 分子量:
- 519.64
- MOL File:
- 219832-49-2.mol
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219832-49-2化学性质
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沸点:
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717.1±70.0 °C(Predicted)
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密度:
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1.28±0.1 g/cm3(Predicted)
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溶解度:
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DMF: 33 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 12 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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7.88±0.10(Predicted)
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颜色:
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Light yellow to yellow
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219832-49-2性质、用途与生产工艺
MP-A08 是一个高度选择性的 ATP 竞争性的 SPHK1 抑制剂。
MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.[2]
MP-A08 suppresses the growth of human lung tumor xenografts in mice.
219832-49-2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-19794 | 219832-49-2
MP-A08 | 219832-49-2 | 1mg | 350元 |
| 2024/11/08 | HY-19794 | 219832-49-2
MP-A08 | 219832-49-2 | 5mg | 550元 |
219832-49-2, 219832-49-2 相关搜索:
- 抑制剂
- 合成有机化合物配体
- 对照品
- 细胞生物学试剂
- MP A08,ATP竞争性SPHK1和2抑制剂
- 4-甲基-N-(2-((2-((4-甲基苯基)磺酰胺基)亚苄基)氨基)苯基)苯磺酰胺
- 化合物MP-A08
- SK抑制剂(MP-A08)
- 219832-49-2
- 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide , MP-A08
- MPA08,SphK,Sphingosine kinase,MP-A-08,inhibit,Inhibitor,MP-A08,MP A08
- 4-Methyl-N-(2-((2-((4-methylphenyl)sulfonamido)benzylidene)amino)phenyl)benzenesulfonamide
- 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide
- Benzenesulfonamide, 4-methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]-
- MP-A08