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ChemicalBook >> CAS DataBase List >> NPS 2390

NPS 2390

NPS 2390 price.
  • $45 - $1190
  • Product name: NPS 2390
  • CAS: 226878-01-9
  • MF: C19H21N3O
  • MW: 307.39
  • EINECS:
  • MDL Number:MFCD05865239
  • Synonyms:N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide;N-(1-adamantyl)quinoxaline-2-carboxamide;N-(Adamantan-1-yl)quinoxaline-2-carboxamide;Inhibitor,NPS2390,Calcium-sensing receptor,NPS-2390,mGluR,inhibit,Metabotropic glutamate receptors,CaSR,NPS 2390;2-Quinoxalinecarboxamide, N-tricyclo[3.3.1.13,7]dec-1-yl-
11 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • CSNpharm
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25MG
  • 50mg
  • ManufacturerAK Scientific
  • Product number6596CQ
  • Product descriptionN-(1-Adamantyl)quinoxaline-2-carboxamide
  • Packaging5mg
  • Price$197
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPEP0003710
  • Product descriptionNPS 2390 95.00%
  • Packaging5MG
  • Price$203.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberPEP0003710
  • Product descriptionNPS 2390 95.00%
  • Packaging25MG
  • Price$906.53
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5532
  • Product descriptionNPS2390
  • Packaging10mg
  • Price$282
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5532
  • Product descriptionNPS2390
  • Packaging50mg
  • Price$1190
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11989
  • Product descriptionNPS 2390 ≥98%
  • Packaging5mg
  • Price$89
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11989
  • Product descriptionNPS 2390 ≥98%
  • Packaging10mg
  • Price$168
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11989
  • Product descriptionNPS 2390 ≥98%
  • Packaging25mg
  • Price$395
  • Updated2024-03-01
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN23007
  • Product descriptionNPS2390
  • Packaging50mg
  • Price$604
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberN899033
  • Product descriptionNPS2390
  • Packaging1mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberN899033
  • Product descriptionNPS2390
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6596CQ N-(1-Adamantyl)quinoxaline-2-carboxamide 5mg $197 2021-12-16 Buy
American Custom Chemicals Corporation PEP0003710 NPS 2390 95.00% 5MG $203.5 2021-12-16 Buy
American Custom Chemicals Corporation PEP0003710 NPS 2390 95.00% 25MG $906.53 2021-12-16 Buy
ApexBio Technology B5532 NPS2390 10mg $282 2021-12-16 Buy
ApexBio Technology B5532 NPS2390 50mg $1190 2021-12-16 Buy
Cayman Chemical 11989 NPS 2390 ≥98% 5mg $89 2024-03-01 Buy
Cayman Chemical 11989 NPS 2390 ≥98% 10mg $168 2024-03-01 Buy
Cayman Chemical 11989 NPS 2390 ≥98% 25mg $395 2024-03-01 Buy
CSNpharm CSN23007 NPS2390 50mg $604 2021-12-16 Buy
TRC N899033 NPS2390 1mg $45 2021-12-16 Buy
TRC N899033 NPS2390 5mg $75 2021-12-16 Buy

Properties

Boiling point :542.4±30.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 50 mM in DMSO and to 50 mM in ethanol
form :Powder
pka :11.53±0.20(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Metabotropic glutamate receptors (mGluRs), mediate excitatory synaptic transmission in the central nervous system. Potent and selective antagonists of the type I mGluRs (mGluR1 and mGluR5) are of interest as novel therapeutics for the treatment of various CNS disorders, such as pain, epilepsy, and stroke. NPS 2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values equal to 5.2 and 82 nM, respectively). At concentrations up to 30 μM, NPS 2390 does not affect mGluR2 or mGluR8 or a standard collection of 37 additional receptors, ion channels, and enzymes. At a dose of 10 mg/kg, NPS 2390 displaced the specifically bound mGlu1R-selective antagonist, [3H]R214127, in rat cerebellum.