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ChemicalBook >> CAS DataBase List >> Necrosulfonamide

Necrosulfonamide

Necrosulfonamide price.
  • $31 - $1792
  • Product name: Necrosulfonamide
  • CAS: 1360614-48-7
  • MF: C18H15N5O6S2
  • MW: 461.47
  • EINECS:
  • MDL Number:MFCD02370191
  • Synonyms:(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfaMoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylaMide;NecrosulfonaMide;(E)-NECROSULFONAMIDE;(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide;100318;CS-2351;Necrosulfonamide (NSA);2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)-
Price40 Properties Safety Information Description
40 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • Adipogen Life Sciences
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Tocris
  • TRC
  • Usbiological
Package
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  • Manufactureraablocks
  • Product numberAA009CKI
  • Product descriptionNecrosulfonamide 98%
  • Packaging5mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA009CKI
  • Product descriptionNecrosulfonamide 98%
  • Packaging25mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA009CKI
  • Product descriptionNecrosulfonamide 98%
  • Packaging50mg
  • Price$329
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA009CKI
  • Product descriptionNecrosulfonamide 98%
  • Packaging100mg
  • Price$409
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32766
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98%
  • Packaging100MG
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3705-M005
  • Product descriptionNecrosulfonamide ≥95%
  • Packaging5mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3705-M025
  • Product descriptionNecrosulfonamide ≥95%
  • Packaging25mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA750842
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+%
  • Packaging1mg
  • Price$31
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA750842
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+%
  • Packaging5mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA750842
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+%
  • Packaging10mg
  • Price$66
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA750842
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+%
  • Packaging25mg
  • Price$86
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA750842
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+%
  • Packaging50mg
  • Price$112
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA750842
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+%
  • Packaging100mg
  • Price$146
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA750842
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+%
  • Packaging250mg
  • Price$219
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA750842
  • Product description(E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+%
  • Packaging1g
  • Price$545
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004750
  • Product descriptionN-[4-[[(3-METHOXY-2-PYRAZINYL)AMINO]SULFONYL]PHENYL]-3-(5-NITRO-2-THIENYL)-, (2E)-2-PROPENAMIDE 95.00%
  • Packaging5MG
  • Price$505.81
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009CKI Necrosulfonamide 98% 5mg $70 2021-12-16 Buy
aablocks AA009CKI Necrosulfonamide 98% 25mg $170 2021-12-16 Buy
aablocks AA009CKI Necrosulfonamide 98% 50mg $329 2021-12-16 Buy
aablocks AA009CKI Necrosulfonamide 98% 100mg $409 2021-12-16 Buy
ACHEMBLOCK O32766 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98% 100MG $350 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3705-M005 Necrosulfonamide ≥95% 5mg $45 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3705-M025 Necrosulfonamide ≥95% 25mg $180 2021-12-16 Buy
Ambeed A750842 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+% 1mg $31 2021-12-16 Buy
Ambeed A750842 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+% 5mg $50 2021-12-16 Buy
Ambeed A750842 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+% 10mg $66 2021-12-16 Buy
Ambeed A750842 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+% 25mg $86 2021-12-16 Buy
Ambeed A750842 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+% 50mg $112 2021-12-16 Buy
Ambeed A750842 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+% 100mg $146 2021-12-16 Buy
Ambeed A750842 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+% 250mg $219 2021-12-16 Buy
Ambeed A750842 (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide 98+% 1g $545 2021-12-16 Buy
American Custom Chemicals Corporation INB0004750 N-[4-[[(3-METHOXY-2-PYRAZINYL)AMINO]SULFONYL]PHENYL]-3-(5-NITRO-2-THIENYL)-, (2E)-2-PROPENAMIDE 95.00% 5MG $505.81 2021-12-16 Buy
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Properties

Melting point :200-204°C(dec.)
Density :1.578±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml)
form :solid
pka :6.37±0.40(Predicted)
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Necrosulfonamide (1360614-48-7) specifically blocks necroptosis downstream of RIP3 activation by preventing MLKL-RIP3 interaction.1 Displays neuroprotective effects after ischemic brain injury.2 Prevents cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells.3 Binds to gasdermin D inhibiting pyroptosis and associated inflammatory cell death and sepsis.4 Rescues cells from TLR3 ligand-induced death.5

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