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ChemicalBook >> CAS DataBase List >> OPC 21268

OPC 21268

OPC 21268 price.
  • $90 - $1900
  • Product name: OPC 21268
  • CAS: 131631-89-5
  • MF: C26H31N3O4
  • MW: 449.54
  • EINECS:
  • MDL Number:MFCD18632552
  • Synonyms:1-[1-[4-(3-Acetylaminopropoxy)benzoyl]-4-piperidyl]-3,4-dihydroquinolin-2(1H)-one;1-{1-[4(3-acetylaminopropoxy)benzoyl]-4-piperidyl}-3,4-dihydro-2(1H)-quinolinone hydrate;N-[3-[4-[[4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide hydrate;OPC-21268 hydrate;N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]acetamide;OPC 21268;N-[3-[4-[4-(2-oxo-3,4-dihydroquinolin-1-yl)piperidine-1-carbonyl]phenoxy]propyl]acetamide;OPC 21268;OPC-21268;OPC21268
22 prices
Selected condition:
Brand
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 10mg
  • 5MG
  • 50
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAK Scientific
  • Product number8170CA
  • Product description1-(1-(4-(3-Acetylaminopropoxy)benzoyl)-4-piperidyl)-3,4-dihydro-2(1H)-quinolinone
  • Packaging10mg
  • Price$403
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number131631895
  • Product descriptionN-(3-(4-(4-(2-Oxo-3,4-dihydroquinolin-1(2H)-yl)piperidine-1-carbonyl)phenoxy)propyl)acetamide
  • Packaging100mg
  • Price$440
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number131631895
  • Product descriptionN-(3-(4-(4-(2-Oxo-3,4-dihydroquinolin-1(2H)-yl)piperidine-1-carbonyl)phenoxy)propyl)acetamide
  • Packaging500mg
  • Price$1212
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0009644
  • Product descriptionN-[3-[4-[[4-(3,4-DIHYDRO-2-OXO-1(2H)QUINOLINYL)-1-PIPERIDINYL]CARBONYL]PHENOXY]PROPYL]-ACETAMIDE 95.00%
  • Packaging5MG
  • Price$503.71
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7537
  • Product descriptionOPC21268
  • Packaging100mg
  • Price$756
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7537
  • Product descriptionOPC21268
  • Packaging25mg
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7537
  • Product descriptionOPC21268
  • Packaging10mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27226
  • Product descriptionOPC 21268
  • Packaging5mg
  • Price$153
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27226
  • Product descriptionOPC 21268
  • Packaging10mg
  • Price$275
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27226
  • Product descriptionOPC 21268
  • Packaging25mg
  • Price$606
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003694
  • Product descriptionFuscoside >98.0%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003694
  • Product descriptionFuscoside >98.0%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003694
  • Product descriptionFuscoside >98.0%
  • Packaging50mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0003694
  • Product descriptionFuscoside >98.0%
  • Packaging100mg
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10726
  • Product descriptionOPC21268 >98%
  • Packaging250mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10726
  • Product descriptionOPC21268 >98%
  • Packaging1g
  • Price$1900
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8170CA 1-(1-(4-(3-Acetylaminopropoxy)benzoyl)-4-piperidyl)-3,4-dihydro-2(1H)-quinolinone 10mg $403 2021-12-16 Buy
Alichem 131631895 N-(3-(4-(4-(2-Oxo-3,4-dihydroquinolin-1(2H)-yl)piperidine-1-carbonyl)phenoxy)propyl)acetamide 100mg $440 2021-12-16 Buy
Alichem 131631895 N-(3-(4-(4-(2-Oxo-3,4-dihydroquinolin-1(2H)-yl)piperidine-1-carbonyl)phenoxy)propyl)acetamide 500mg $1212 2021-12-16 Buy
American Custom Chemicals Corporation API0009644 N-[3-[4-[[4-(3,4-DIHYDRO-2-OXO-1(2H)QUINOLINYL)-1-PIPERIDINYL]CARBONYL]PHENOXY]PROPYL]-ACETAMIDE 95.00% 5MG $503.71 2021-12-16 Buy
ApexBio Technology B7537 OPC21268 100mg $756 2021-12-16 Buy
ApexBio Technology B7537 OPC21268 25mg $315 2021-12-16 Buy
ApexBio Technology B7537 OPC21268 10mg $189 2021-12-16 Buy
Cayman Chemical 27226 OPC 21268 5mg $153 2024-03-01 Buy
Cayman Chemical 27226 OPC 21268 10mg $275 2024-03-01 Buy
Cayman Chemical 27226 OPC 21268 25mg $606 2024-03-01 Buy
ChemScene CS-0003694 Fuscoside >98.0% 5mg $90 2021-12-16 Buy
ChemScene CS-0003694 Fuscoside >98.0% 10mg $120 2021-12-16 Buy
ChemScene CS-0003694 Fuscoside >98.0% 50mg $280 2021-12-16 Buy
ChemScene CS-0003694 Fuscoside >98.0% 100mg $480 2021-12-16 Buy
DC Chemicals DC10726 OPC21268 >98% 250mg $1000 2021-12-16 Buy
DC Chemicals DC10726 OPC21268 >98% 1g $1900 2021-12-16 Buy

Properties

Boiling point :772.5±60.0 °C(Predicted)
Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
pka :16.17±0.46(Predicted)
form :powder
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

OPC 21268 is a nonpeptide antagonist of vasopressin V1 receptors (IC50 = 0.4 μM in rat liver membranes). It is selective for V1 over V2 receptors (IC50 = >100 μM in kidney membranes). It is also selective for rat over human V1 receptors (Kis = 25 and 8,800 nM, respectively), which can be partially attributed to the alanine residue at position 337 of the rat sequence, instead of a glycine residue in the human sequence, with differences at positions 224, 310, and 324 also contributing. OPC 21268 (0.03-1 mg/kg, i.v.) inhibits pressor responses induced by arginine vasopressin (argipressin; ) in pithed rats and arginine vasopressin-induced vasoconstriction in conscious rats (ID50 = 2 mg/kg). It induces hypotension in aged spontaneously hypertensive rats (SHRs) and stroke-prone SHRs when administered at a dose of 3 mg/kg.