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ChemicalBook >> CAS DataBase List >> PI3K inhibitor

PI3K inhibitor

PI3K inhibitor price.
  • $105 - $2084
  • Product name: PI3K inhibitor
  • CAS: 1202884-94-3
  • MF: C31H35F3N8O3
  • MW: 624.66
  • EINECS:-0
  • MDL Number:MFCD18251469
  • Synonyms:PI3K inhibitor;Antitumor Drug;CAY10626;BenzaMide, N-[2-(diMethylaMino)ethyl]-N-Methyl-4-[[[[4-[4-(4-Morpholinyl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyriMidin-2-yl]phenyl]aMino]carbonyl]aMino]-;N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl}carbamoyl)amino]benzamide;PI3K-IN-22
8 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • TRC
Package
  • 1mg
  • 2.5mg
  • 5MG
  • 10mg
  • 25mg
  • ManufacturerAK Scientific
  • Product number3628DF
  • Product descriptionN-[2-(Dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]carbamoylamino]benzamide
  • Packaging10mg
  • Price$1007
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3628DF
  • Product descriptionN-[2-(Dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]carbamoylamino]benzamide
  • Packaging25mg
  • Price$2084
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0316610
  • Product descriptionN-[2-(DIMETHYLAMINO)ETHYL]-N-METHYL-4-[[[[4-[4-(4-MORPHOLINYL)-7-(2,2,2-TRIFLUOROETHYL)-7H-PYRROLO-[2,3-D]PYRIMIDIN-2-YL]PHENYL]AMINO]CARBONYL]AMINO]-BENZAMIDE 95.00%
  • Packaging5MG
  • Price$495.61
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13838
  • Product descriptionCAY10626 ≥98%
  • Packaging1mg
  • Price$105
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13838
  • Product descriptionCAY10626 ≥98%
  • Packaging5mg
  • Price$459
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13838
  • Product descriptionCAY10626 ≥98%
  • Packaging10mg
  • Price$816
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13838
  • Product descriptionCAY10626 ≥98%
  • Packaging25mg
  • Price$1783
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberC227025
  • Product descriptionCAY10626
  • Packaging2.5mg
  • Price$295
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3628DF N-[2-(Dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]carbamoylamino]benzamide 10mg $1007 2021-12-16 Buy
AK Scientific 3628DF N-[2-(Dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]carbamoylamino]benzamide 25mg $2084 2021-12-16 Buy
American Custom Chemicals Corporation HCH0316610 N-[2-(DIMETHYLAMINO)ETHYL]-N-METHYL-4-[[[[4-[4-(4-MORPHOLINYL)-7-(2,2,2-TRIFLUOROETHYL)-7H-PYRROLO-[2,3-D]PYRIMIDIN-2-YL]PHENYL]AMINO]CARBONYL]AMINO]-BENZAMIDE 95.00% 5MG $495.61 2021-12-16 Buy
Cayman Chemical 13838 CAY10626 ≥98% 1mg $105 2024-03-01 Buy
Cayman Chemical 13838 CAY10626 ≥98% 5mg $459 2024-03-01 Buy
Cayman Chemical 13838 CAY10626 ≥98% 10mg $816 2024-03-01 Buy
Cayman Chemical 13838 CAY10626 ≥98% 25mg $1783 2024-03-01 Buy
TRC C227025 CAY10626 2.5mg $295 2021-12-16 Buy

Properties

Density :1.35±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 15 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
form :A crystalline solid
pka :13.74±0.70(Predicted)

Safety Information

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Description

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3, important second messengers that modulate the activity of downstream targets Akt and mTOR. Aberrant PI3K/Akt is associated with many human cancers. CAY10626 is a potent, dual PI3Kα/mTOR inhibitor with IC50 values of 0.9 and 0.6 nM for the two respective kinases. In a tumor cell growth inhibition assay, CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. When administered at 25-50 mg/k to MD361 xenograft mice, phosphorylation of the downstream targets of PI3Kα and mTOR (Akt T308, Akt S473, and S6K) was suppressed, and significant tumor regression was observed.