PRT-060318
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- $41 - $1782
- Product name: PRT-060318
- CAS: 1194961-19-7
- MF: C18H24N6O
- MW: 340.42
- EINECS:
- MDL Number:MFCD28155088
- Synonyms:PRT-060318;PRT-060318(PRT318);2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(3-methylphenyl)amino]-5-pyrimidinecarboxamide;P 142-76;PRT 318;2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide;CS-1688;PRT-060318 ≥95%
29 prices
Selected condition：
Brand
- Adipogen Life Sciences
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1204-M001
- Product descriptionPRT-060318 ≥95%
- Packaging1mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1204-M050
- Product descriptionPRT-060318 ≥95%
- Packaging50mg
- Price$1782
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424910
- Product description2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+%
- Packaging1mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424910
- Product description2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+%
- Packaging5mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424910
- Product description2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+%
- Packaging10mg
- Price$176
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424910
- Product description2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+%
- Packaging25mg
- Price$334
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424910
- Product description2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+%
- Packaging50mg
- Price$599
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA424910
- Product description2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+%
- Packaging100mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002594
- Product descriptionPRT-060318 95.00%
- Packaging5MG
- Price$497.87
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6161
- Product descriptionPRT-060318
- Packaging5mg
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6161
- Product descriptionPRT-060318
- Packaging50mg
- Price$961
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22476
- Product descriptionPRT060318 ≥98%
- Packaging5mg
- Price$144
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22476
- Product descriptionPRT060318 ≥98%
- Packaging10mg
- Price$274
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22476
- Product descriptionPRT060318 ≥98%
- Packaging25mg
- Price$502
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM248100
- Product descriptionPRT-060318(PRT318) 95%
- Packaging100mg
- Price$449
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6283
- Product descriptionPRT-060318 99.50%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1204-M001 | PRT-060318 ≥95% | 1mg | $162 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1204-M050 | PRT-060318 ≥95% | 50mg | $1782 | 2021-12-16 | Buy |
| Ambeed | A424910 | 2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+% | 1mg | $41 | 2021-12-16 | Buy |
| Ambeed | A424910 | 2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+% | 5mg | $98 | 2021-12-16 | Buy |
| Ambeed | A424910 | 2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+% | 10mg | $176 | 2021-12-16 | Buy |
| Ambeed | A424910 | 2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+% | 25mg | $334 | 2021-12-16 | Buy |
| Ambeed | A424910 | 2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+% | 50mg | $599 | 2021-12-16 | Buy |
| Ambeed | A424910 | 2-(((1R,2S)-2-Aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide 98+% | 100mg | $850 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0002594 | PRT-060318 95.00% | 5MG | $497.87 | 2021-12-16 | Buy |
| ApexBio Technology | B6161 | PRT-060318 | 5mg | $158 | 2021-12-16 | Buy |
| ApexBio Technology | B6161 | PRT-060318 | 50mg | $961 | 2021-12-16 | Buy |
| Cayman Chemical | 22476 | PRT060318 ≥98% | 5mg | $144 | 2024-03-01 | Buy |
| Cayman Chemical | 22476 | PRT060318 ≥98% | 10mg | $274 | 2024-03-01 | Buy |
| Cayman Chemical | 22476 | PRT060318 ≥98% | 25mg | $502 | 2024-03-01 | Buy |
| Chemenu | CM248100 | PRT-060318(PRT318) 95% | 100mg | $449 | 2021-12-16 | Buy |
| ChemScene | CS-6283 | PRT-060318 99.50% | 5mg | $120 | 2021-12-16 | Buy |
Properties
Melting point :152 - 155°C
Boiling point :602.1±65.0 °C(Predicted)
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Refrigerator, under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :14.10±0.50(Predicted)
color :Pale Brown
Boiling point :602.1±65.0 °C(Predicted)
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Refrigerator, under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :14.10±0.50(Predicted)
color :Pale Brown
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
PRT060318 is a potent and selective inhibitor of spleen tyrosine kinase (Syk; IC50 = 4 nM). It is selective, inhibiting 92% of Syk activity, while other kinases retain >70% activity, at a concentration of 50 nM in a panel of 270 kinases. PRT060318 inhibits convulxin-induced aggregation of human platelet-rich plasma (IC50 = 2.5 μM) in vitro and prevents thrombosis in a transgenic mouse model of heparin-induced thrombocytopenia. It induces chronic lymphocytic leukemia (CLL) B cell apoptosis and inhibits the secretion of chemokines CCL3, CCL4, and CXCL13. PRT060318 also inhibits CLL B cell chemotaxis and pseudoemperipolesis.More related product prices
NSC 600157Related product price
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