PlatensiMycin
|
- $347 - $1249
- Product name: PlatensiMycin
- CAS: 835876-32-9
- MF: C24H27NO7
- MW: 441.474
- EINECS:
- MDL Number:MFCD14635440
- Synonyms:PlatensiMycin;Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem;Benzoic acid, 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-;laminomycin
7 prices
Selected condition：
Brand
- Cayman Chemical
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 250ug
- 250μg
- 500μg
- 1mg
- ManufacturerCayman Chemical
- Product number15507
- Product descriptionPlatensimycin ≥95%
- Packaging250μg
- Price$347
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15507
- Product descriptionPlatensimycin ≥95%
- Packaging1mg
- Price$1249
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number528244
- Product descriptionPlatensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF.
- Packaging250μg
- Price$405
- Updated2022-05-15
- Buy
- ManufacturerTRC
- Product numberP578205
- Product descriptionPlatensimycin
- Packaging250μg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP578205
- Product descriptionPlatensimycin
- Packaging500μg
- Price$560
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product numberP4262-20
- Product descriptionPlatensimycin
- Packaging250ug
- Price$582
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number462737
- Product descriptionPlatensimycin
- Packaging250μg
- Price$722
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 15507 | Platensimycin ≥95% | 250μg | $347 | 2024-03-01 | Buy |
| Cayman Chemical | 15507 | Platensimycin ≥95% | 1mg | $1249 | 2024-03-01 | Buy |
| Sigma-Aldrich | 528244 | Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF. | 250μg | $405 | 2022-05-15 | Buy |
| TRC | P578205 | Platensimycin | 250μg | $350 | 2021-12-16 | Buy |
| TRC | P578205 | Platensimycin | 500μg | $560 | 2021-12-16 | Buy |
| Usbiological | P4262-20 | Platensimycin | 250ug | $582 | 2021-12-16 | Buy |
| Usbiological | 462737 | Platensimycin | 250μg | $722 | 2021-12-16 | Buy |
Properties
Melting point :220-222 °C(Solv: nitromethane (75-52-5))
Boiling point :683.1±55.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble1mg/mL, clear, colorless
pka :2.14±0.13(Predicted)
form :Tan solid
color :white to beige
Boiling point :683.1±55.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble1mg/mL, clear, colorless
pka :2.14±0.13(Predicted)
form :Tan solid
color :white to beige
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance. PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg.Suppliers and manufacturers
BOC Sciences
Hangzhou MolCore BioPharmatech Co.,Ltd.
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Shaanxi Xianhe Biotech Co., Ltd
Lynnchem
Novachemistry
Shanghai Hongye Biotechnology Co. Ltd
Shenzhen Polymeri Biochemical Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Meng Cheng Technology (Shanghai) Co., LTD