PlatensiMycin
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- $347 - $1249
- Product name: PlatensiMycin
- CAS: 835876-32-9
- MF: C24H27NO7
- MW: 441.474
- EINECS:
- MDL Number:MFCD14635440
- Synonyms:PlatensiMycin;Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem;Benzoic acid, 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-;laminomycin
7 prices
Selected condition：
Brand
- Cayman Chemical
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 250ug
- 250μg
- 500μg
- 1mg
- ManufacturerCayman Chemical
- Product number15507
- Product descriptionPlatensimycin ≥95%
- Packaging250μg
- Price$347
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15507
- Product descriptionPlatensimycin ≥95%
- Packaging1mg
- Price$1249
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number528244
- Product descriptionPlatensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF.
- Packaging250μg
- Price$405
- Updated2022-05-15
- Buy
- ManufacturerTRC
- Product numberP578205
- Product descriptionPlatensimycin
- Packaging250μg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP578205
- Product descriptionPlatensimycin
- Packaging500μg
- Price$560
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product numberP4262-20
- Product descriptionPlatensimycin
- Packaging250ug
- Price$582
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number462737
- Product descriptionPlatensimycin
- Packaging250μg
- Price$722
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 15507 | Platensimycin ≥95% | 250μg | $347 | 2024-03-01 | Buy |
| Cayman Chemical | 15507 | Platensimycin ≥95% | 1mg | $1249 | 2024-03-01 | Buy |
| Sigma-Aldrich | 528244 | Platensimycin, Streptomyces sp. - CAS 835876-32-9 - Calbiochem A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF. | 250μg | $405 | 2022-05-15 | Buy |
| TRC | P578205 | Platensimycin | 250μg | $350 | 2021-12-16 | Buy |
| TRC | P578205 | Platensimycin | 500μg | $560 | 2021-12-16 | Buy |
| Usbiological | P4262-20 | Platensimycin | 250ug | $582 | 2021-12-16 | Buy |
| Usbiological | 462737 | Platensimycin | 250μg | $722 | 2021-12-16 | Buy |
Properties
Melting point :220-222 °C(Solv: nitromethane (75-52-5))
Boiling point :683.1±55.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble1mg/mL, clear, colorless
pka :2.14±0.13(Predicted)
form :Tan solid
color :white to beige
Boiling point :683.1±55.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble1mg/mL, clear, colorless
pka :2.14±0.13(Predicted)
form :Tan solid
color :white to beige
Safety Information
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Description
Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance. PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg.Suppliers and manufacturers
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