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ChemicalBook >> CAS DataBase List >> RI-1

RI-1

RI-1 price.
  • $5 - $2691.1
  • Product name: RI-1
  • CAS: 415713-60-9
  • MF: C14H11Cl3N2O3
  • MW: 361.61
  • EINECS:
  • MDL Number:MFCD00814248
  • Synonyms:RI-1;3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione;RI-1, >=98%;RAD51 inhibitor RI-1;RAD51 inhibitor 1;3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-;RI-1 >=98% (HPLC)
41 prices
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  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
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  • 5mg
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  • 1g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product number2687AH
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
  • Packaging100mg
  • Price$142
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2687AH
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
  • Packaging250mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA194418
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+%
  • Packaging1mg
  • Price$5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA194418
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+%
  • Packaging5mg
  • Price$8
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA194418
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+%
  • Packaging10mg
  • Price$11
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA194418
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+%
  • Packaging50mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA194418
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+%
  • Packaging100mg
  • Price$27
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA194418
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+%
  • Packaging250mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA194418
  • Product description3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+%
  • Packaging1g
  • Price$105
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0001876
  • Product description3-CHLORO-1-(3,4-DICHLOROPHENYL)-4-MORPHOLINO-1H-PYRROLE-2,5-DIONE 95.00%
  • Packaging10MG
  • Price$245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3764
  • Product descriptionRI-1
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3764
  • Product descriptionRI-1
  • Packaging10mM(in 1mL DMSO)
  • Price$83
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3764
  • Product descriptionRI-1
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3764
  • Product descriptionRI-1
  • Packaging50mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1885
  • Product descriptionRI-1 99%
  • Packaging10mg
  • Price$104.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1885
  • Product descriptionRI-1 99%
  • Packaging2x10mg
  • Price$154
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2687AH 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione 100mg $142 2021-12-16 Buy
AK Scientific 2687AH 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione 250mg $182 2021-12-16 Buy
Ambeed A194418 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+% 1mg $5 2021-12-16 Buy
Ambeed A194418 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+% 5mg $8 2021-12-16 Buy
Ambeed A194418 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+% 10mg $11 2021-12-16 Buy
Ambeed A194418 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+% 50mg $20 2021-12-16 Buy
Ambeed A194418 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+% 100mg $27 2021-12-16 Buy
Ambeed A194418 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+% 250mg $42 2021-12-16 Buy
Ambeed A194418 3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 98+% 1g $105 2021-12-16 Buy
American Custom Chemicals Corporation INB0001876 3-CHLORO-1-(3,4-DICHLOROPHENYL)-4-MORPHOLINO-1H-PYRROLE-2,5-DIONE 95.00% 10MG $245.7 2021-12-16 Buy
ApexBio Technology A3764 RI-1 5mg $75 2021-12-16 Buy
ApexBio Technology A3764 RI-1 10mM(in 1mL DMSO) $83 2021-12-16 Buy
ApexBio Technology A3764 RI-1 10mg $130 2021-12-16 Buy
ApexBio Technology A3764 RI-1 50mg $500 2021-12-16 Buy
Axon Medchem Axon1885 RI-1 99% 10mg $104.5 2021-12-16 Buy
Axon Medchem Axon1885 RI-1 99% 2x10mg $154 2021-12-16 Buy

Properties

Boiling point :483.0±45.0 °C(Predicted)
Density :1.61
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :-3.45±0.20(Predicted)
form :powder
color :yellow to orange
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.

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