ROLAPITANT HYDROCHLORIDE
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- $170 - $11880
- Product name: ROLAPITANT HYDROCHLORIDE
- CAS: 914462-92-3
- MF: C25H29ClF6N2O3
- MW: 554.96
- EINECS:682-730-5
- MDL Number:MFCD23105917
- Synonyms:Rolapitant Hydrochloride Hydrate;RolapitantMonohydrochloride;ROLAPITANT HYDROCHLORIDE;1,7-Diazaspiro[4.5]decan-2-one, 8-[[(1R)-1-[3,5-bis(trifluoroMethyl)phenyl]ethoxy]Methyl]-8-phenyl-, Monohydrochloride, Monohydrate, (5S,8S)-;(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one,hydrate,hydrochloride;Rolapitant Hydrochloride Monohydrate;Rolapitant HCl hydrate;1,7-Diazaspiro[4.5]decan-2-one, 8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-, hydrochloride, hydrate (1:1:1), (5S,8S)-
10 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Biosynth Carbosynth
- Matrix Scientific
- TRC
Package
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- ManufacturerAK Scientific
- Product number2857CW
- Product descriptionRolapitanthydrochloride
- Packaging25mg
- Price$387
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014111
- Product descriptionROLAPITANT 95.00%
- Packaging1G
- Price$10905.3
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0014111
- Product descriptionROLAPITANT 95.00%
- Packaging5MG
- Price$498.99
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR162254
- Product descriptionRolapitant hydrochloride monohydrate
- Packaging250mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR162254
- Product descriptionRolapitant hydrochloride monohydrate
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR162254
- Product descriptionRolapitant hydrochloride monohydrate
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR162254
- Product descriptionRolapitant hydrochloride monohydrate
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR162254
- Product descriptionRolapitant hydrochloride monohydrate
- Packaging10mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number125261
- Product descriptionRolapitant 95+%
- Packaging1g
- Price$11880
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberR424505
- Product descriptionRolapitantHydrochlorideHydrate
- Packaging5mg
- Price$275
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2857CW | Rolapitanthydrochloride | 25mg | $387 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014111 | ROLAPITANT 95.00% | 1G | $10905.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014111 | ROLAPITANT 95.00% | 5MG | $498.99 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR162254 | Rolapitant hydrochloride monohydrate | 250mg | $600 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR162254 | Rolapitant hydrochloride monohydrate | 100mg | $450 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR162254 | Rolapitant hydrochloride monohydrate | 50mg | $350 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR162254 | Rolapitant hydrochloride monohydrate | 25mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FR162254 | Rolapitant hydrochloride monohydrate | 10mg | $170 | 2021-12-16 | Buy |
| Matrix Scientific | 125261 | Rolapitant 95+% | 1g | $11880 | 2021-12-16 | Buy |
| TRC | R424505 | RolapitantHydrochlorideHydrate | 5mg | $275 | 2021-12-16 | Buy |
Properties
Melting point :>149oC (dec.)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | ||||||||||||||||||||||
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Description
Rolapitant hydrochloride hydrate, originally discovered by Schering-Plough and later developed by TESARO, Inc., was approved by the FDA in September 2015 for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in combination with other antiemetic agents. Rolapitant is a highly selective NK-1 receptor antagonist, exhibiting >1000- fold selectivity for NK-1 over human NK-2 and NK-3 receptors in vitro. In contrast to other NK-1 inhibitors that play an essential role in delayed CINV therapy, rolapitant shows no inhibition of CYP3A4, eliminating the need for concern when coadministering with CYP34A substrates. Additionally, rolapitant is an orally active agent with a relatively long half-life (180 h), providing potential opportunities for single- and prechemotherapy-based treatments. In three large clinical trials involving patients receiving moderately emetogenic chemotherapy (MEC) and highly emetogenic chemotherapy (HEC), subjects using rolapitant as a cotherapy with granisetron and dexamethasone showed a significant improvement in complete response compared to those receiving treatments of granisetron and dexamethasone.More related product prices
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