S14161
|
- $45 - $640
- Product name: S14161
- CAS: 883046-50-2
- MF: C17H14FNO4
- MW: 315.2957632
- EINECS:
- MDL Number:MFCD00112055
- Synonyms:S14161;8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran;SAG Analog (LowTox);2H-1-Benzopyran, 8-ethoxy-2-(4-fluorophenyl)-3-nitro-
8 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Cayman Chemical
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 2.5mg
- 5mg
- 10mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3516-M005
- Product descriptionS14161 ≥99%(NMR)
- Packaging5mg
- Price$238
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1206CH
- Product description8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene
- Packaging5mg
- Price$415
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14187
- Product descriptionS14161 ≥99%
- Packaging1mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14187
- Product descriptionS14161 ≥99%
- Packaging5mg
- Price$286
- Updated2024-03-01
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number72298
- Product descriptionS14161
- Packaging2.5mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberS080730
- Product descriptionS14161
- Packaging1mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberS080730
- Product descriptionS14161
- Packaging10mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number045265
- Product descriptionS14161
- Packaging1mg
- Price$297
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3516-M005 | S14161 ≥99%(NMR) | 5mg | $238 | 2021-12-16 | Buy |
| AK Scientific | 1206CH | 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene | 5mg | $415 | 2021-12-16 | Buy |
| Cayman Chemical | 14187 | S14161 ≥99% | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 14187 | S14161 ≥99% | 5mg | $286 | 2024-03-01 | Buy |
| Medical Isotopes, Inc. | 72298 | S14161 | 2.5mg | $640 | 2021-12-16 | Buy |
| TRC | S080730 | S14161 | 1mg | $45 | 2021-12-16 | Buy |
| TRC | S080730 | S14161 | 10mg | $340 | 2021-12-16 | Buy |
| Usbiological | 045265 | S14161 | 1mg | $297 | 2021-12-16 | Buy |
Properties
Boiling point :456.2±45.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: soluble
form :A solid
color :Yellow
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: soluble
form :A solid
color :Yellow
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.More related product prices
AnilineRelated product price
- Aniline
$10-1418.92
Suppliers and manufacturers
Aladdin Scientific
J & K SCIENTIFIC LTD.
Shanghai Tauto Biotech Co., Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shenzhen Polymeri Biochemical Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Energy Chemical
TargetMol Chemicals Inc.
Shanghai Yingxin laboratory equipment Co., Ltd
Shanghai Guchen Biotechnology Co., LTD