S14161
- CAS No.
- 883046-50-2
- Chemical Name:
- S14161
- Synonyms
- S14161;SAG Analog (LowTox);8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran;2H-1-Benzopyran, 8-ethoxy-2-(4-fluorophenyl)-3-nitro-
- CBNumber:
- CB02677978
- Molecular Formula:
- C17H14FNO4
- Molecular Weight:
- 315.2957632
- MDL Number:
- MFCD00112055
- MOL File:
- 883046-50-2.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315 | |||||||||
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362+P364 | |||||||||
NFPA 704 |
|
S14161 price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 14187 | S14161 ≥99% | 883046-50-2 | 1mg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 14187 | S14161 ≥99% | 883046-50-2 | 5mg | $286 | 2024-03-01 | Buy |
Usbiological | 045265 | S14161 | 883046-50-2 | 1mg | $297 | 2021-12-16 | Buy |
TRC | S080730 | S14161 | 883046-50-2 | 10mg | $340 | 2021-12-16 | Buy |
TRC | S080730 | S14161 | 883046-50-2 | 1mg | $45 | 2021-12-16 | Buy |
S14161 Chemical Properties,Uses,Production
Description
D-
Uses
D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s < 10 μM) but is less toxic to normal hematopoietic cells (IC20 > 25 μM). In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.[Cayman Chemical]
Uses
S14161 is a small-molecule inhibitor of D-cyclin transactivation that displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
storage
+4°C
S14161 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Shanghai Yingxin laboratory equipment Co., Ltd | 021-021-59178156 15300768757 | 359382369@qq.com | China | 10678 | 58 |
Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 | 1986399151@qq.com | China | 9849 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28070 | 58 |