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ChemicalBook >> CAS DataBase List >> SP 141

SP 141

SP 141 price.
  • $44 - $1700
  • Product name: SP 141
  • CAS: 1253491-42-7
  • MF: C22H16N2O
  • MW: 324.38
  • EINECS:
  • MDL Number:MFCD29059920
  • Synonyms:SP 141;6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-;SP 141;SP141;;6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole;6-Methoxy-1-(1-naphthyl)-9H-β-carboline;pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141
15 prices
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Brand
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • DC Chemicals
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number5674DP
  • Product description6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
  • Packaging1mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number5674DP
  • Product description6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
  • Packaging10mg
  • Price$313
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4120
  • Product descriptionSP141
  • Packaging10mg
  • Price$219
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2437
  • Product descriptionSP141 99%
  • Packaging10mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17003
  • Product descriptionSP 141 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17003
  • Product descriptionSP 141 ≥98%
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17003
  • Product descriptionSP 141 ≥98%
  • Packaging10mg
  • Price$193
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17003
  • Product descriptionSP 141 ≥98%
  • Packaging50mg
  • Price$849
  • Updated2024-03-01
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8599
  • Product descriptionSP141 >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8599
  • Product descriptionSP141 >98%
  • Packaging250mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8599
  • Product descriptionSP141 >98%
  • Packaging1g
  • Price$1700
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number5332
  • Product descriptionSP141 ≥98%(HPLC)
  • Packaging10
  • Price$208
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number5332
  • Product descriptionSP141 ≥98%(HPLC)
  • Packaging50
  • Price$870
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberS678500
  • Product descriptionSP141
  • Packaging5mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number256718
  • Product descriptionSP 141
  • Packaging10mg
  • Price$460
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5674DP 6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole 1mg $147 2021-12-16 Buy
AK Scientific 5674DP 6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole 10mg $313 2021-12-16 Buy
ApexBio Technology C4120 SP141 10mg $219 2021-12-16 Buy
Axon Medchem Axon2437 SP141 99% 10mg $132 2021-12-16 Buy
Cayman Chemical 17003 SP 141 ≥98% 1mg $44 2024-03-01 Buy
Cayman Chemical 17003 SP 141 ≥98% 5mg $118 2024-03-01 Buy
Cayman Chemical 17003 SP 141 ≥98% 10mg $193 2024-03-01 Buy
Cayman Chemical 17003 SP 141 ≥98% 50mg $849 2024-03-01 Buy
DC Chemicals DC8599 SP141 >98% 100mg $500 2021-12-16 Buy
DC Chemicals DC8599 SP141 >98% 250mg $900 2021-12-16 Buy
DC Chemicals DC8599 SP141 >98% 1g $1700 2021-12-16 Buy
Tocris 5332 SP141 ≥98%(HPLC) 10 $208 2021-12-16 Buy
Tocris 5332 SP141 ≥98%(HPLC) 50 $870 2021-12-16 Buy
TRC S678500 SP141 5mg $95 2021-12-16 Buy
Usbiological 256718 SP 141 10mg $460 2021-12-16 Buy

Properties

Boiling point :571.2±45.0 °C(Predicted)
Density :1.284±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form :crystalline solid
pka :15.04±0.40(Predicted)
color :White to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Mouse double minute 2 protein (Mdm2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM). Binding of Mdm2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.