Skepinone-L
|
- $49 - $2525
- Product name: Skepinone-L
- CAS: 1221485-83-1
- MF: C24H21F2NO4
- MW: 425.42
- EINECS:
- MDL Number:MFCD22572738
- Synonyms:5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-;Skepinone-L, >=98%;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;Skepinone-L;2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one;CS-1010;SKEPINONE
21 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX5940
- Product descriptionSkepinone-L
- Packaging1mg
- Price$199
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX5940
- Product descriptionSkepinone-L
- Packaging10mg
- Price$837
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3824
- Product descriptionSkepinone-L
- Packaging5mg
- Price$287
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0248
- Product descriptionSkepinone-L
- Packaging1mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0248
- Product descriptionSkepinone-L
- Packaging5mg
- Price$421
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0248
- Product descriptionSkepinone-L
- Packaging10mg
- Price$537
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16974
- Product descriptionSkepinone-L ≥98%
- Packaging500μg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16974
- Product descriptionSkepinone-L ≥98%
- Packaging1mg
- Price$92
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16974
- Product descriptionSkepinone-L ≥98%
- Packaging5mg
- Price$380
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16974
- Product descriptionSkepinone-L ≥98%
- Packaging10mg
- Price$665
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0941
- Product descriptionSkepinone-L
- Packaging5mg
- Price$343
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0941
- Product descriptionSkepinone-L
- Packaging10mg
- Price$443
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0941
- Product descriptionSkepinone-L
- Packaging50mg
- Price$1195
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004227
- Product descriptionSkepinone-L 98+%
- Packaging5mg
- Price$285
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7765
- Product descriptionSkepinone-L >98%
- Packaging250mg
- Price$1100
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7765
- Product descriptionSkepinone-L >98%
- Packaging1g
- Price$2200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5940 | Skepinone-L | 1mg | $199 | 2021-12-16 | Buy |
| AK Scientific | X5940 | Skepinone-L | 10mg | $837 | 2021-12-16 | Buy |
| ApexBio Technology | A3824 | Skepinone-L | 5mg | $287 | 2021-12-16 | Buy |
| Apolloscientific | BISN0248 | Skepinone-L | 1mg | $218 | 2021-12-16 | Buy |
| Apolloscientific | BISN0248 | Skepinone-L | 5mg | $421 | 2021-12-16 | Buy |
| Apolloscientific | BISN0248 | Skepinone-L | 10mg | $537 | 2021-12-16 | Buy |
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 500μg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 1mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 5mg | $380 | 2024-03-01 | Buy |
| Cayman Chemical | 16974 | Skepinone-L ≥98% | 10mg | $665 | 2024-03-01 | Buy |
| ChemScene | CS-0941 | Skepinone-L | 5mg | $343 | 2021-12-16 | Buy |
| ChemScene | CS-0941 | Skepinone-L | 10mg | $443 | 2021-12-16 | Buy |
| ChemScene | CS-0941 | Skepinone-L | 50mg | $1195 | 2021-12-16 | Buy |
| Crysdot | CD31004227 | Skepinone-L 98+% | 5mg | $285 | 2021-12-16 | Buy |
| DC Chemicals | DC7765 | Skepinone-L >98% | 250mg | $1100 | 2021-12-16 | Buy |
| DC Chemicals | DC7765 | Skepinone-L >98% | 1g | $2200 | 2021-12-16 | Buy |
Properties
Melting point :130-134°C
Boiling point :629.0±55.0 °C(Predicted)
Density :1.384±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.49±0.20(Predicted)
form :Solid
color :Light Yellow to Yellow
Boiling point :629.0±55.0 °C(Predicted)
Density :1.384±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.49±0.20(Predicted)
form :Solid
color :Light Yellow to Yellow
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM). It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells. At 1 μM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin , blunting platelet secretion and aggregation.More related product prices
936091-26-8 PP2 TAK-632 Saracatinib 1,9-Pyrazoloanthrone MK-2206 2HCl Sitravatinib Sitaxentan sodium Sivelestat sodiumRelated product price
- 936091-26-8
$28-3250 - PP2
$9-5040 - TAK-632
$28-2691.1