TAPI-2
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- $144 - $1540
- Product name: TAPI-2
- CAS: 187034-31-7
- MF: C19H37N5O5
- MW: 415.53
- EINECS:
- MDL Number:MFCD04119706
- Synonyms:TAPI-2;N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-T-BUTYL-ALANYL-L-ALANINE, 2-AMINOETHYL AMIDE;N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-T-BUTYL-GLYCYL-L-ALANINE 2-AMINOETHYL AMIDE;TNF-ALPHA PROTEASE INHIBITOR-2;HONHCOCH2CH(CH2-CH(CH3)2)CO-T-LEU-ALA-NHCH2CH2NH2;N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide;N-[2-[2-(HydroxyaMino)-2-oxoethyl]-4-Methyl-1-oxopentyl]-3-Methyl-L-valyl-N-(2-aMinoethyl)-L-alaninaMide Acetic Acid;CS-2628
16 prices
Selected condition：
Brand
- Alfa Aesar
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1
- 500μg
- 1mg
- 5mg
- 10mg
- ManufacturerAlfa Aesar
- Product numberJ64330
- Product descriptionTAPI-2
- Packaging1mg
- Price$325
- Updated2023-06-20
- Buy
- ManufacturerCayman Chemical
- Product number14695
- Product descriptionTAPI-2 ≥95%
- Packaging500μg
- Price$150
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14695
- Product descriptionTAPI-2 ≥95%
- Packaging1mg
- Price$253
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6143
- Product descriptionTAPI-2
- Packaging1mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6143
- Product descriptionTAPI-2
- Packaging5mg
- Price$720
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6143
- Product descriptionTAPI-2
- Packaging10mg
- Price$1140
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN19037
- Product descriptionTAPI-2
- Packaging1mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8131
- Product descriptionTAPI-2(TNFProteaseInhibitor2) 95.900%
- Packaging5mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8131
- Product descriptionTAPI-2(TNFProteaseInhibitor2) 95.900%
- Packaging10mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number579052
- Product descriptionTAPI-2 - CAS 187034-31-7 - Calbiochem
- Packaging1mg
- Price$475
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product number5.09612
- Product descriptionInSolution TAPI-2 - CAS 187034-31-7 - Calbiochem
- Packaging1mg
- Price$490
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number6013
- Product descriptionTAPI2 ≥95%(HPLC)
- Packaging1
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberH791950
- Product descriptionN-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamideAceticAcid
- Packaging1mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberH791950
- Product descriptionN-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamideAceticAcid
- Packaging5mg
- Price$865
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberH791950
- Product descriptionN-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamideAceticAcid
- Packaging10mg
- Price$1540
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number169753
- Product descriptionTAPI-2
- Packaging1mg
- Price$542
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Alfa Aesar | J64330 | TAPI-2 | 1mg | $325 | 2023-06-20 | Buy |
| Cayman Chemical | 14695 | TAPI-2 ≥95% | 500μg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 14695 | TAPI-2 ≥95% | 1mg | $253 | 2024-03-01 | Buy |
| ChemScene | CS-6143 | TAPI-2 | 1mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-6143 | TAPI-2 | 5mg | $720 | 2021-12-16 | Buy |
| ChemScene | CS-6143 | TAPI-2 | 10mg | $1140 | 2021-12-16 | Buy |
| CSNpharm | CSN19037 | TAPI-2 | 1mg | $144 | 2021-12-16 | Buy |
| DC Chemicals | DC8131 | TAPI-2(TNFProteaseInhibitor2) 95.900% | 5mg | $400 | 2021-12-16 | Buy |
| DC Chemicals | DC8131 | TAPI-2(TNFProteaseInhibitor2) 95.900% | 10mg | $650 | 2021-12-16 | Buy |
| Sigma-Aldrich | 579052 | TAPI-2 - CAS 187034-31-7 - Calbiochem | 1mg | $475 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.09612 | InSolution TAPI-2 - CAS 187034-31-7 - Calbiochem | 1mg | $490 | 2024-03-01 | Buy |
| Tocris | 6013 | TAPI2 ≥95%(HPLC) | 1 | $288 | 2021-12-16 | Buy |
| TRC | H791950 | N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamideAceticAcid | 1mg | $195 | 2021-12-16 | Buy |
| TRC | H791950 | N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamideAceticAcid | 5mg | $865 | 2021-12-16 | Buy |
| TRC | H791950 | N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamideAceticAcid | 10mg | $1540 | 2021-12-16 | Buy |
| Usbiological | 169753 | TAPI-2 | 1mg | $542 | 2021-12-16 | Buy |
Properties
Density :1.127±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Ethanol: 5 mg/ml; Water: 8 mg/ml
form :Solid
pka :9.17±0.20(Predicted)
color :White to off-white
Sensitive :Light Sensitive & Hygroscopic
storage temp. :Store at -20°C
solubility :Ethanol: 5 mg/ml; Water: 8 mg/ml
form :Solid
pka :9.17±0.20(Predicted)
color :White to off-white
Sensitive :Light Sensitive & Hygroscopic
Safety Information
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Description
The extracellular domains of many different types of transmembrane proteins, including growth factors, growth factor receptors and cell adhesion molecules, are proteolytically released (shed) in response to environmental cues. TNF protease inhibitor 2 (TAPI-2) is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE), other ADAMs (a disintegrin and metalloproteinases), and other matrix metalloproteinases. It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit, with an IC50 value of 10 μM. TAPI-2 inhibits ADAM8, 10, 12, and TACE with Ki values of 10, 3, 100, and 0.12 μM, respectively. In T4-2 breast cancer cells, 20 μM TAPI-2 prevented mobilization of the growth factors TGF-α and amphiregulin leading to reversion of the malignant cellular phenotype.More related product prices
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